总之,本研究鉴定了一个有助于SCC化疗耐药的关键非编码RNA DLGAP1-AS2(D-AS2),其在化疗耐药SCC细胞中升高并与代谢事件相关。研究结果表明DLGAP1-AS2介导的磷脂酸合成激活YAP信号通路并赋予鳞状细胞癌的化疗耐药。 原文链接: https://aacrjournals.org/cancerres/article-abstract/doi/10.1158/0008-5472.CAN...
研究者发现DLGAP1-AS2通过与Elongin A(Elongin A,Elongin A)的物理相互作用促进肿瘤的发生和转移,并通过促进含有21(Trim21)的三个基序(Trim21)介导的泛素化修饰和ELOA的降解来抑制其蛋白质稳定性,从而促进肿瘤的发生和转移。 特别是,研究者发现DLGAP1-AS2通过抑制ELOA介导的LHPP的转录激活,从而阻断LHPP依赖的AKT信号...
为了进一步阐明D-AS2在体内的功能,作者将对照或D-AS2过表达的UM1细胞皮下移植到裸鼠体内,并在一周后给予生理盐水或DDP处理。与体外实验结果一致,D-AS2过表达UM1细胞显示出较低的生长速率,并对DDP抗药性增加(Fig. 2C),而在亲本KYSE...
The long noncoding RNA (lncRNA) DLGAP1-AS2 has recently been characterized as an oncogenic lncRNA in several cancers. However, its biological roles and clinical significance in gastric cancer (GC) remains barely understood. In this study, we performed a systematic analysis of DLGAP1-AS2 ...
Molecular Cancer: 长非编码RNA DLGAP1-AS2通过调节Trim21/ELOA/LHPP轴促进结直肠癌的发生和转移 来源:生物谷原创 2022-11-28 17:38 结直肠癌(CRC)是全球第三大常见恶性肿瘤,也是全球第二大癌症相关死亡原因。结直肠癌的发病率不断增加,据估计,2020年约有190万例新发结直肠癌病例,93.5万人死亡。
(Log-rank P<0.001),且DLGAP1-AS2高表达为ccRCC患者预后的独立危险因素(均P<0.05).基于DLGAP1-AS2构建了列线图,经验证可以较好地预测ccRCC患者生存率.结论过表达DLGAP1-AS2能够通过抑制PI3K/Akt/mTOR通路,抑制786-O细胞的增殖活性和免疫逃逸.DLGAP1-AS2高表达预示ccRCC患者预后不良.DLGAP1-AS2是ccRCC潜在的治疗...
DLGAP1-AS2ELOALHPPLong noncoding RNAsTrim21Background:Long noncoding RNAs (lncRNAs) have driven research focused on their effects as oncogenes or tumor suppressors involved in carcinogenesis. However, the functions and mechanisms of most lncRNAs in colorectal cancer (CRC) remain unclear. Methods:The...
DLGAP1-AS2 expression level was also correlated with age (p =0.0008), lymphatic and vascular invasion (p =0.0415) in internal samples. Also, a significant correlation was found between DLGAP1-AS2 and YAP1 expression, as its valid downstream target, in GC samples. Besides, analysis of other ...
Methods:HR8348-R cells, radioresistant cells from HR8348 after irradiation, were isolated into CD133 negative (CD133 Results:The DLGAP1-AS2 level was increased in CD133 Conclusion:DLGAP1-AS2 accelerates the radioresistance of rectal cancer cells through interactions with E2F1 to upregulate CD151 ...
However, DLGAP1-AS2 overexpression accelerated the progression of OS. We further found that DLGAP1-AS2 upregulation was induced by hypoxia and low glucose. Additionally, DLGAP1-AS2 bound to miR-451a to upregulate HK2 expression. Rescue assays revealed that the DLGAP1-AS2/miR-451a/HK2 axis ...