Contact co-culture of dissociated embryonic stem cells (ESC)s and embryoid bodies (EB)s with HEI-OC1 cells induced differentiation into otic cells. (A) Methodology of contact co-culture is shown. HEI-OC1 cells
Mouse embryonic stem (ES) cells are derived from mouse blastocyst and are able to generate all embryonic tissues in vitro. This propensity of ES cells has acquired considerable attention in recent years due to the promising potential for future cell replacement-based therapies. Therefore, it is ...
(hPSCs). Stem cells that have the potential to form any cell type of the human body. They include human embryonic stem cells (hESCs) and human induced pluripotent stem cells (iPSCs). All hPSCs have the same ability to differentiate into cells of distinct lineages, such as neurons. Human ...
AbstractThe recent breakthrough in the generation of rat embryonic stem cells (rESCs) opens the door to application of gene targeting to create models for the study of human diseases. In addition, the in vitro differentiation system from rESCs into derivatives of three germ layers will serve as...
This set of candidate phosphoprotein regulators of stem cell differentiation includes products of genes previously noted to be enriched in embryonic stem cells at the mRNA expression level as well as proteins not associated previously with stem cell differentiation status....
Embryonic stem (ES) cells are characterized by pluripotency, defined as the developmental potential to generatecell lineagesderived from all three primarygerm layers. In the past decade, great progress has been made on the cell culture conditions, transcription factor programs and intracellularsignaling ...
Generation of lymphohematopoietic cells from embryonic stem cells in culture An efficient system was developed that induced the differentiation of embryonic stem (ES) cells into blood cells of erythroid, myeloid, and B cell lineages... T Nakano,H Kodama,T Honjo - 《Science》 被引量: 1602发表:...
Researchers have shown that adult satellite cells originated from progenitor cells that first expressed the myogenic assay gene MYF5 in the fetal stage of myogenesis [21] (see Figure 1). In addition, during embryonic development, Wnt signals control the expression of myogenic regulatory factors (...
The potential of human embryonic stem (hES) cells to differentiate into cell types of a variety of organs has generated much excitement over the possible use of hES cells in therapeutic applications. Of great interest are organs derived from definitive e
Polycomb repressive complex 1 (PRC1) is an important regulator of gene expression and development. PRC1 contains the E3 ligases RING1A/B, which monoubiquitinate lysine 119 at histone H2A (H2AK119ub1), and has been sub-classified into six major complexes