Stem-cell differentiation is the process by which a more specialised cell is formed from a stem cell, leading to loss of some of the stem cell's developmental potential. Stem-cell differentiation occurs during development of an organism to produce new specialised cells, and also in adults to ...
The differentiation of neural stem cells (NSCs) into neurons is proposed to be critical in devising potential cell-based therapeutic strategies for central nervous system (CNS) diseases, however, the determination and prediction of differentiation is complex and not yet clearly established, especially ...
现代细胞分化概念的起源可以追溯到奥古斯特·魏斯曼 (August Weismann, 1893) 的有影响力的著作《生殖质理论》(The Theory of the Germ Plasm) 。 Weismann 提出的概念是在胚胎发生早期产生了两种细胞类型:一种将个体的遗传信息传递给下一代(性腺中的生殖细胞),另一种产生有机体中的所有其他细胞类型(体细胞)。这意...
controlling self-renewal and differentiation of stem cells via mechanical cues通过机械控制干细胞的自我更新和分化的暗示 Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology Volume 2012, Article ID 797410, 12 pages doi:10.1155/2012/797410 Review Article Controlling Self-Renewal and ...
The 3D bioprinting of stem cells directly into scaffolds offers great potential for the development of regenerative therapies; in particular for the fabrication of organ and tissue substitutes. For this to be achieved; the lineage fate of bioprinted stem cell must be controllable. Bioprinting can be...
These δ cells display mature RNA profiles and fine secretory granules, secrete somatostatin in response to various stimuli, and suppress insulin secretion from in vitro co-cultured β cells and mouse β cells upon transplantation. The generation of human pancreatic δ cells from stem cells in ...
Generation of lymphohematopoietic cells from embryonic stem cells in culture An efficient system was developed that induced the differentiation of embryonic stem (ES) cells into blood cells of erythroid, myeloid, and B cell lineages... T Nakano,H Kodama,T Honjo - 《Science》 被引量: 1594发表:...
The stromal cell fraction of many tissues and organs has shown in vitro neurogenic differentiation; however, these cell types are limited by availability, invasiveness of extraction and in some cases limited proliferative capacity. Human endometrial adult stem cells have many clinical advantages over ...
Summary The in vitro aggregation of human embryonic stem (ES) cells into three dimensional clusters, termed embryoid bodies (EB), allows for the spontaneous differentiation of cells representing endoderm, mesoderm and ectoderm lineages. During EB differentiation, the stochastic generation of hematopoietic...
Recent research demonstrates that CNTF also plays an important role in neurogenesis and the differentiation of neural stem cells. In this article, we summarize the general characteristics of CNTF and its function on neural stem cells, which could be a valuable therapeutic strategy in treating ...