Methods: A 'top-down and bottom-up' approach was used, based on clinical case examples and adaptations from the Overt Aggression Scale - Modifi ed for Neurorehabilitation (OAS-MNR) (Alderman et al, 1997). Inter-rater reliability, face and content validity were tested through opportunistic ...
Differentiating Co-Occurring Behavior Problems in Children With ADHD: Patterns of Emotional Reactivity and Executive Functioning Objective: This study examined whether "top-down" and "bottom-up" control processes can differentiate children with ADHD who exhibit co-occurring aggressio... PA Graziano,McNam...
Using a bottom-up (i.e. black-box) approach, standard class prediction algorithms were able to predict dietary responders with up to 61.1%+/-8.1% accuracy. Using a top-down approach (i.e. using differentially expressed genes to build a classifier) improved prediction accuracy to 80.9%+/-...
To test whether the up- and down-regulated sequences identified in our mRNAseq study provided valid protein targets to reverse fibrosis, we assessed the ability of more than 30 anti-integrin blocking antibodies to promote or inhibit myofibroblast differentiation. Myofibroblasts are defined by their mo...
They reported relatively preserved performance among the Williams syndrome children, and poor performance among the children with Down's syndrome. While this approach for measuring sustained attention is common practice when studying toddlers, the play context differs significantly from classic sustained ...
In breast cancer cell lines, overexpression of miR-221 and miR-222 has been shown to be involved in the EGFR–RAS–RAF–MEK pathway and to down- regulate p27Kip1 and PTEN leading to elevated cell proliferation (Miller et al, 2008; Garofalo et al, 2009). Moreover, there is evidence ...
Notably, patients with GAD were featured by intense emotional experiences coupled with excessive NSRP, but fail to down-regulate their emotions and somatic responses (Fresco et al., 2017). Previous studies have revealed associations between greater NSRP and higher GAD symptoms in college students (La...
Well, it all comes down to the quality of your questioning and listening skills. AConsultative Sales approachis a must when it comes down to understanding needs and wants. It’s not a one-way sales pitch here. Instead, you should be asking lots of questions around why they w...
It didn't really pick up, I didn't really officially start until 2007. That's when I actually formed the LLC, and I was starting to try and sell the product to my friends. My first order was 400, and the hard part was actually trying to track down the product. I mean I had ...
Structural complexity is known to influence prey behaviour, mortality and population structure, but the effects on predators have received less attention. We tested whether contrasting structural complexity in two newly colonised lakes (low structural co