Activation of caspase-3 by terpenoids and flavonoids in different types of cancer cellsBinding energyFlavonoidsMolecular interactionActivation constantTerpenoidsCaspase-3Background: Caspase-3 is accountable for the execution of apoptosis. Recently, it has gained attention as a promising target for the ...
Cancer is the disease in which one experiences uncontrolled growth of cells anywhere in the body. When one has cancer, old cells that are meant to die do not die, and the remaining cells divide and form new cells uncontrollably. Cancer may be caused by biological factors, environmental ...
is recognized as an oncogene in human small cell lung cancer (SCLC), which is an aggressive neuroendocrine (NE) tumor. However, the role of SOX2 in SCLC is not completely understood, and strategies to selectively target SOX2 in SCLC cells remain elusive. Here, we show, using next-generation...
An abnormal and uncontrolled division of cells is termed as cancer, Genes called cellular oncogenes (c-onc) or proto-oncogens present in normal cells when activated under certain conditions lead oncogenic transformation of the normal cells leading canc
DNA from tumours could reveal cancers earlier A simple blood test can detect eight different types of cancer. It does this by detecting the various sizes of tumour DNA fragments that flow through the body. At the moment, most cancer screening tools are l
The emergence and maintenance of cancer stem-like cells (CSCs) are usually governed by tumor niche. Tumor niche always provides metabolic challenges to cancer cells and CSCs mostly because of tissue hypoxia. However, the role of micro-environmental nutri
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These proteins include cytotoxic T lymphocyte-associated protein 4 (CTLA-4) and programmed death-1 (PD-1) on T cells, as well as its ligand PD-L1 on cancer cells. However, while ICIs may increase immune activity against tumour cells, they can also decrease immune tolerance to self-antigen...
Since the cancer stem cell concept has been widely accepted, several strategies have been proposed to attack cancer stem cells (CSC). Accordingly, stem cell markers are now preferred therapeutic targets. However, the problem of tumor specificity has not disappeared but shifted to another question: ...
for instance, are vastly different in structure and function from cells of the skeletal system. Cells of the body depend on each other to keep the body functioning as a unit. There are hundreds of types of cells, but the following are the 11 most common. ...