2024年9月25日,Nature同期连发两篇重磅研究Single-cell CAR T atlas reveals type 2 function in 8-year leukaemia remission和A type 2 cytokine Fc–IL-4 revitalizes exhausted CD8+ T cells against cancer,揭示了Type-2免疫在维...
3. Gao, S., Hsu, T. W. & Li, M. O. Immunity beyond cancer cells: perspective from tumor tissue.Trends in Cancer7, 1010–1019 (2021). 4. Xhangolli, I. et al. Single-cell Analysis of CAR-T Cell Activa...
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Type 2 diabetes is characterized by the resistance of the body’s cells to insulin. Of the 184 countries included in the Nature Medicine study, all saw an increase in type 2 diabetes cases between 1990 and 2018, representing a growing burden on individuals, families, and healthcare systems. ...
A pivotal question arises as to whether type 2 immunity can be orchestrated alongside type 1-centric immunotherapy to achieve enduring response against cancer3,4. Here we show that an interleukin-4 fusion protein (Fc–IL-4), a typical type 2 cytokine, directly acts on CD8+ T cells and ...
Tissue-resident memory T (TRM) cells, functionally distinct from circulating memory T cells, have a critical role in protective immunity in tissues, are more efficacious when elicited after vaccination and yield more effective antitumor immunity, yet the
Researchers from Karolinska Institutet have made a significant breakthrough in the study of childhood neuroblastoma, a type of cancer that begins before birth during the early stages of adrenal gland development. By sequencing DNA and RNA in tens of thousands ofsingle cellsfrom human tumors, the gr...
Myeloid-derived suppressor cells CXCR4: C-X-C chemokine receptor type 4 NF-κB: Nuclear factor-kappa B NLRP3: NLR family pyrin domain containing 3 ICIs: Immune checkpoint inhibitors PD-1: Programmed cell death protein-1 PD-L1: Programmed cell death ligand siRNAs: short interfering RN...
Type 2 immunity is often regarded as an unfavorable antitumor response since it allows cancer cells to evade the immune system. However, recent human epidemiological data suggest that the type 2 response can be an effective defense mechanism against cancer. For instance, there is an inverse ...
Unrestrained cancer immunity ignites atherosclerosis Researchers map the expression of immune checkpoints and cell interactions within human atherosclerotic plaques, and the influence of relevant comorbidities such as dyslipidemia and diabetes. The findings shed light on the potential mechanisms behind the incr...