Several multi-cancer GWAS loci within the region encoding telomerase reverse transcriptase (TERT) have been identified. Here, the authors explore the locus within TERT intron 4, link it with a variable number tandem repeat (VNTR), and investigate its biological significance and role in cancer. ...
et al. SRSF2 is essential for hematopoiesis, and its myelodysplastic syndrome-related mutations dysregulate alternative pre-mRNA splicing. Mol. Cell. Biol. 35, 3071–3082 (2015). CAS PubMed PubMed Central Google Scholar Palangat, M. et al. The splicing factor U2AF1 contributes to cancer ...
and metastasis of many types of cancer, including BC. However, the significance of TNFR2 in BC biology is not fully understood.This reviewprovides an overview of TNFR2 biology, detailing its activation and its interactions with important signaling pathways in the TME (e.g., NF-κB, MAPK, an...
"The Cancer Genome Atlas (TCGA)," funded by the National Institutes of Health, completed the genetic sequencing and analyses of about 10,000 tumors from patients spanning 33 types of cancer, and focused on identifying similarities between cancers based on changes in their genes, and the way the...
the sun can be quite healthy for you. In fact, recent studies have found that [19]/[20]sunlight can actually help protect you from certain types of cancer such as breast and stomach. More importantly, [21]the sun also provides us with our main source of Vitamin D. M: Well, I don'...
center’s major assets is its ability to serve across sectors at the local, regional, and national levels. Since the center’s creation, its clients have included top companies doing cutting-edge work in pharma, biotech, and diagnostics; the world’s leading cancer centers; and hea...
Recent emerging data suggest that YAP1 regulate CSCs properties and confer therapy resistance [46, 47]. Overexpression of YAP1 and its activation (nuclear localization) are associated with poor prognosis in several tumor types, including gastric adenocarcinoma (GAC). We have demonstrated that YAP1 ...
Although having previously demonstrated that nuclear [87] and mitochondrial [64,69] genetics could alter metastatic efficiency, it was recognized that all cells in F1progeny would inherit mtDNA from the MNX mother. We therefore investigated the role of mtDNA in the tumor microenvironment and its imp...
“Glutathione S-transferase M1 and its variants A and B as host factors of bladder cancer susceptibility: a case-control study”. Cancer Research 1994; 54: 4103–4111. Google Scholar Bronner CE and 17 others, including Fishel R and Kolodner R. “Mutation in the DNA mismatch repair gene ...
3.2. Estimated numbers of cancer deaths and cancer mortality rates The estimated numbers of total deaths for all cancers and 26 cancer types stratified by sex were shown in Table 3. About 2,413,500 people died from cancer in China in 2016. Lung cancer was the most common cause of cancer ...