Given the growing population of Latino/a immigrants 60 years and older and the current lack of relevant data, our study aimed to understand the knowledge of gender-specific types of cancer among older Latinos/as to ensure effective prevention, intervention, and cancer care. Using convenience ...
While cancer-specific survival rate was in favor of patients who undergo early RC for high-risk NMIBC, significant proportion of patients still would be overtreated. In addition, the potential morbidity and mortality of the RC must be taken into consideration. Therefore the careful follow-u...
Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior and therapeutic response of this disease are poorly und
Transcriptional heterogeneity among malignant cells of a tumor has been studied in individual cancer types and shown to be organized into cancer cell states; however, it remains unclear to what extent these states span tumor types, constituting general features of cancer. Here, we perform a pan-ca...
[21] have searched for cancer regulatory programs that link transcription factors to target genes that are conditionally activated in specific types or subtypes of cancer. Their results have suggested that alterations in pathways that active some transcription factors might be responsible for the ...
CD4+ T cells play key roles in a range of immune responses, either as direct effectors or through accessory cells, including CD8+ T lymphocytes. In cancer, neoantigen (NeoAg)-specific CD8+ T cells capable of direct tumor recognition have been extensively studied, whereas the role of NeoAg-...
As expected, the majority of NC fusion types were B4N (12 of 18, 67%). B4N fusion-specific siRNA treatment on NC cells showed specific inhibitory effects on the B4N fusion transcript and fusion protein without affecting the endogenous expression of the parent genes, resulting in decreased r...
RNA splicing dysregulation and the hallmarks of cancer 2023, Nature Reviews Cancer RNA-binding motif protein 39 (RBM39): An emerging cancer target 2022, British Journal of Pharmacology Altered RNA processing in cancer pathogenesis and therapy 2019, Cancer Discovery Aberrant RNA splicing in cancer 2019...
Transposable elements (TE) are repetitive genomic elements that harbor binding sites for human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal development and diseases such as cancer but systematic investigation of t
To examine the performance of C.Origami in discovering new chromatin interactions in rearranged cancer genomes, we predicted Hi-C contact matrices at the translocation locus in CUTTL1 (Fig. 4c–e and Methods). We found that C.Origami prediction accurately captured the neo-TAD structure spanning ...