Given the growing population of Latino/a immigrants 60 years and older and the current lack of relevant data, our study aimed to understand the knowledge of gender-specific types of cancer among older Latinos/as to ensure effective prevention, intervention, and cancer care. Using convenience ...
Metastatic gastric carcinoma is a highly lethal cancer that responds poorly to conventional and molecularly targeted therapies. Despite its clinical relevance, the mechanisms underlying the behavior and therapeutic response of this disease are poorly und
While cancer-specific survival rate was in favor of patients who undergo early RC for high-risk NMIBC, significant proportion of patients still would be overtreated. In addition, the potential morbidity and mortality of the RC must be taken into consideration. Therefore the careful follow-u...
Transcriptional heterogeneity among malignant cells of a tumor has been studied in individual cancer types and shown to be organized into cancer cell states; however, it remains unclear to what extent these states span tumor types, constituting general features of cancer. Here, we perform a pan-ca...
[21] have searched for cancer regulatory programs that link transcription factors to target genes that are conditionally activated in specific types or subtypes of cancer. Their results have suggested that alterations in pathways that active some transcription factors might be responsible for the ...
CD4+ T cells play key roles in a range of immune responses, either as direct effectors or through accessory cells, including CD8+ T lymphocytes. In cancer, neoantigen (NeoAg)-specific CD8+ T cells capable of direct tumor recognition have been extensively studied, whereas the role of NeoAg-...
This is aspecificfor cancer. 这是一种治疗癌症的特效药. 《简明英汉词典》 This disease isspecificto this area. 这种疾病只发生在这一地区. 《简明英汉词典》 There are twospecific( al ) questions we must answer. 有两个具体问题我们必须回答. ...
As expected, the majority of NC fusion types were B4N (12 of 18, 67%). B4N fusion-specific siRNA treatment on NC cells showed specific inhibitory effects on the B4N fusion transcript and fusion protein without affecting the endogenous expression of the parent genes, resulting in decreased r...
Cancer vaccines can both generate new antigen-specific T cell responses and amplify existing responses and thereby focus the host immune response against tumour cells. Because of this ability to induce and direct a potent and tumour-specific immune response while minimizing autoimmunity, a cancer vacci...
Transposable elements (TE) are repetitive genomic elements that harbor binding sites for human transcription factors (TF). A regulatory role for TEs has been suggested in embryonal development and diseases such as cancer but systematic investigation of t