Carcinoma is a type ofcancerthat starts in cells that make up theskinor the tissue lining organs, such as theliverorkidneys. Like other types ofcancer,carcinomasare abnormal cells that divide without control. They are able to spread to other parts of the body, but don't always. "Carcinoma...
Fibrillin-1 demonstrated a cytoplasmic location in the neoplastic cells of almost all carcinomas apart from the follicular ones. The most intense staining was observed in papillary carcinomas with some evidence of a slight increased intensity in advanced stages. Our data indicate that fibrillin-1 is...
Carcinosarcoma—rare malignant solid tumors that arise in different organs and are formed by two types of cancerous cells that have the potential to metastasize: carcinoma (or epithelial cancer) and sarcoma (or connective/mesenchymal tissue cancer). It is a very aggressive biphasic solid tumor th...
discuss the regulatory signaling that controls their individual and collective functions. Most of these observations stem from the study of carcinomas, in which the neoplastic epithelial cells constitute a comp 我们这里列举一套知道的细胞类型贡献用重要方式对许多肿瘤生物和谈论控制他们各自和集体作用的管理...
stimulating hormone (i.e., α-MSH) occurred in the mouse allograft models of Lewis lung carcinoma (LLC), MC38 colon adenocarcinoma, MCA205 fibrosarcoma, or B16-F10 melanoma, stimulating the generation of myeloid-derived suppressor cells (MDSCs) to dampen antitumor immunity.18Despite these ...
Based on evidence from morphological and histochemical studies and from clinical experience, the following hypotheses are proposed: (1) carcinoma-in-situ (CIS) germ cells are malignant gonocytes; (2) these CIS gonocytes have some capacity to regress into more primitive, totipotent embryonic cells...
Transcriptional heterogeneity among malignant cells of a tumor has been studied in individual cancer types and shown to be organized into cancer cell states; however, it remains unclear to what extent these states span tumor types, constituting general features of cancer. Here, we perform a pan-ca...
Conditioned media prepared from human lung, placenta, peripheral leukocytes, cultured human pancreatic carcinoma cells, and cultured cervical carcinoma cells exhibit a common pattern of two distinct colony-stimulating factors (CSF) separable by isoelectrofocusing. Type I CSF appears polydisperse on isoele...
Thetriple-negative breast cancersubtype however, is not susceptible to estrogens or anti-estrogens. This type of carcinoma occurs mainly in pre-menopausal women and often lacks effective treatment options. "Our initial idea was to induce estrogen receptor expression in order to convert triple-negative...
Cytotoxic effects of desipramine on human colon carcinoma HT29 and HCT116 cells were examined. Desipramine reduced the viability of HT29 cells in a concentration-dependent manner, but failed to cause any significant change in the viability of HCT116 cells by the concentration up to 50 μmo...