Genetics can play a significant role, especially in cancers like chest adenocarcinoma, where mutations in genes like BRCA1 and BRCA2 increase risk. 4 How does adenocarcinoma spread? Like other cancers, adenocarcinoma can spread through the body via the lymphatic system or bloodstream, leading to me...
Higher cancer risk was related to BRCT domain of BRCA1 for breast cancer, and BRC repeats of BRCA2 for ovarian cancer. Parity was a risk-reducing factor among BRCA1/2 mutation carriers. Risk factors can be used for personalized preventive strategies of BRCA1/2 mutation carriers.Park, Ji ...
Screening for germ-line rearrangements and regulatory mutations in BRCA1 led to the identification of four new deletions. Most previous mutation screening studies conducted on breast families were aimed at identifying mutations in the coding sequence and splice sites. Mutations in the promoter and ...
www.nature.com/scientificreports OPEN Two novel AGXT mutations identified in primary hyperoxaluria type-1 and distinct morphological received: 25 April 2016 accepted: 30 August 2016 Published: 20 September 2016 and structural difference in kidney stones Cui Wang1,2, Jingru Lu1,2,*,Yanhua ...
Molecular dynamics simulations show that the loss of interactions is most severe forY240S, which agrees with the thermal stability of the mutations. In conclusion, our study shows that SAM increases the stability of TPMT and that changing only one amino acid can have a dramatic effect on TPMT...
Breast cancer happens when breast cells mutate and become cancerous cells, dividing and multiplying to create tumors, which include mutations in genes such as BRCA1, BRCA2, Tp53, HER2, etc. Fibroadenoma is caused by the changing levels of the hormone estrogen. ...
and irregularly shaped and sized small clusters of calcified cells. DCIS forms when genetic mutations likeBRCA1 and BRCA2 mutationsoccur in the DNA of breast duct cells. There are several risk factors for DCIS, including age (adults are affected more), family history, not becoming pregnant, giv...
The article presents a study which examines the difference of triple negative breast cancer (TNBC), basal-like breast cancer (BLBC) and BRCA1 associated breast cancer (BABC). The study describes the pathology and biology of the three groups of tumor such as the definition of triple negative ...
Basal-like breast cancer was delineated using this methodology and demonstrates significant overlap with so-called triple negative and BRCA1-associated breast carcinomas. This article describes the pathology and biology of these three groups of tumours and examines the relationship between them. ...
of the prostate gland caused by the changes in the balance of sex hormones. Prostate cancer is a tumor growth in the prostate gland caused by inherited genetic mutations in genes such as BRCA1, BRCA2, and HOXB13. So, this is the key difference between enlarged prostate and prostate canc...