Higher cancer risk was related to BRCT domain of BRCA1 for breast cancer, and BRC repeats of BRCA2 for ovarian cancer. Parity was a risk-reducing factor among BRCA1/2 mutation carriers. Risk factors can be used for personalized preventive strategies of BRCA1/2 mutation carriers.Park, Ji ...
MDM-2, Rb, BRCA-1, BRCA-2, CDKN-1B, CDKN-1A, andCDKN-1Bhave shown to be associated with PCa progression14,15, and EBV has been shown to modulate several of these genes in other cancer types4,16, however, the EBV-associated dysregulation of gene expression in PCa has not been expl...
Screening for germ-line rearrangements and regulatory mutations in BRCA1 led to the identification of four new deletions. Most previous mutation screening studies conducted on breast families were aimed at identifying mutations in the coding sequence and splice sites. Mutations in the promoter and ...
[low metastatic potential]) were used in the study.The invasion ability of the two cell lines was evaluated with wound healing assay,cell adhesion assay,and transwell assay;real-time fluorescence quantitative PCR was used to identify gene expressions associated with the invasion ability and cellular...
Yanhua Lang1,*, Ting Liu1,2,*, Xiaoling Wang1,2,*, Xiangzhong Zhao2 & Leping Shao1,2 Primary hyperoxaluria type 1 (PH1) is a rare genetic disease characterized by excessive oxalate accumulation in plasma and urine, resulting in various phenotypes because of allelic and clinical ...
The article presents a study which examines the difference of triple negative breast cancer (TNBC), basal-like breast cancer (BLBC) and BRCA1 associated breast cancer (BABC). The study describes the pathology and biology of the three groups of tumor such as the definition of triple negative ...
Basal-like breast cancer was delineated using this methodology and demonstrates significant overlap with so-called triple negative and BRCA1-associated breast carcinomas. This article describes the pathology and biology of these three groups of tumours and examines the relationship between them. ...
Sara Helander2,*, Anna Zimdahl Kahlin2, Chun Wah Cheng1, Chi Chung Shek1, Moon Ho Leung3, Björn Wallner4, Lars-Göran Mårtensson5 & Malin Lindqvist Appell2 Thiopurine induced toxicity is associated with defects in the thiopurine methyltransferase (TPMT) gene....
gene, resulting in an altered enzymatic activity for the TPMT protein, with increased incorporation of TGNs into DNA as a result of the altered activity8. Since 1980 it has been known that TPMT is a polymorphic enzyme and so far around 40 allelic variants of the TPMT enzyme have been ...
life Article Representational Difference Analysis of Transcripts Involved in Jervine Biosynthesis Magdalena Szeliga 1,* , Joanna Ciura 1,2 and Mirosław Tyrka 1 1 Department of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, Powstan´ ców Warszawy 6 Ave, ...