Higher cancer risk was related to BRCT domain of BRCA1 for breast cancer, and BRC repeats of BRCA2 for ovarian cancer. Parity was a risk-reducing factor among BRCA1/2 mutation carriers. Risk factors can be used for personalized preventive strategies of BRCA1/2 mutation carriers.Park, Ji ...
MDM-2, Rb, BRCA-1, BRCA-2, CDKN-1B, CDKN-1A, andCDKN-1Bhave shown to be associated with PCa progression14,15, and EBV has been shown to modulate several of these genes in other cancer types4,16, however, the EBV-associated dysregulation of gene expression in PCa has not been expl...
expression levels of intercellular adhesion molecule 1 (ICAM-1) and breast cancer suppressor candidate 1 (BCSC-1) in MDA-MB-231 cells were 0.09±0.01 and 0.15±0.03,significantly lower than those in MCF-7 cells (both P<0.01);but the matrix metalloproteinase 14 (MMP-14) expression level in...
www.nature.com/scientificreports OPEN Two novel AGXT mutations identified in primary hyperoxaluria type-1 and distinct morphological received: 25 April 2016 accepted: 30 August 2016 Published: 20 September 2016 and structural difference in kidney stones Cui Wang1,2, Jingru Lu1,2,*,Yanhua ...
The article presents a study which examines the difference of triple negative breast cancer (TNBC), basal-like breast cancer (BLBC) and BRCA1 associated breast cancer (BABC). The study describes the pathology and biology of the three groups of tumor such as the definition of triple negative ...
Basal-like breast cancer was delineated using this methodology and demonstrates significant overlap with so-called triple negative and BRCA1-associated breast carcinomas. This article describes the pathology and biology of these three groups of tumours and examines the relationship between them. ...
The correlation between TPMT genotype and SAM levels is further emphasized by the fact that heterozygous TPMT*1/*3 individuals with high SAM levels show a more pronounced enzymatic effect compared to individuals with low SAM levels25. To gain further insight into the possible stabilizing effect of...
between the secondary structures for TPMTwt, TPMT p.Y240C and TPMT p.Y240S could be observed and the global secondary structures were not affected by the addition of either 10 or 50-fold molar excess of SAM (Fig. 2). Further, we analyzed the thermal unfolding process and changes in ...
life Article Representational Difference Analysis of Transcripts Involved in Jervine Biosynthesis Magdalena Szeliga 1,* , Joanna Ciura 1,2 and Mirosław Tyrka 1 1 Department of Biotechnology and Bioinformatics, Faculty of Chemistry, Rzeszow University of Technology, Powstan´ ców Warszawy 6 Ave, ...