Due to a large intragenic deletion, BRCA1 function cannot be restored in this tumor model by secondary mutations (Liu et al., 2007). As the underlying mechanism of secondary resistance we frequently observed an
Higher cancer risk was related to BRCT domain of BRCA1 for breast cancer, and BRC repeats of BRCA2 for ovarian cancer. Parity was a risk-reducing factor among BRCA1/2 mutation carriers. Risk factors can be used for personalized preventive strategies of BRCA1/2 mutation carriers.Park, Ji ...
while prostate cancer is the growth of a tumor in the prostate gland due to inherited genetic mutations in genes such asBRCA1,BRCA2,andHOXB13. Thus, this is the key difference between enlarged prostate and prostate cancer. Furthermore, the risk factors for an enlarged...
What is the difference between a germline cancer, such as those caused by BRCA1 mutations, and cancers caused by somatic mutations in the same gene in the same cell? Which are cancer-causing genes in mice and humans? a. totipotent genes b. proto-oncogenes c. oncogenes d. ...
Several studies have shown an association between prostate carcinoma (PCa) and Epstein-Barr virus (EBV); however, none of the studies so far have identified the histopathological and genetic markers of cancer aggressiveness associated with EBV in PCa tis
Basal-like breast cancer was delineated using this methodology and demonstrates significant overlap with so-called triple negative and BRCA1-associated breast carcinomas. This article describes the pathology and biology of these three groups of tumours and examines the relationship between them. ...
The article presents a study which examines the difference of triple negative breast cancer (TNBC), basal-like breast cancer (BLBC) and BRCA1 associated breast cancer (BABC). The study describes the pathology and biology of the three groups of tumor such as the definition of triple negative ...
(nautical) The angular difference at the vessel between the direction of true north and magnetic north. Magnetic declination Mutation As now employed (first by de Vries), a cellular process resulting in a sudden inheritable variation (the offspring differing from its parents in some well-marked ch...
Tp, fc and γ indicate the pulse width, carrier frequency, and frequency modulation rate, respectively. Assume that there are K targets in the scene of radar observation. During the accumulation time, the distance between the maneuvering target and radar can be approximated as second order, i....