of the remaining talks concentrated on attempts to demonstrate functionality for BRCA1 and BRCA2.Daniel Haber (Massachusetts General Hospital and Cancer Centre, Boston) and Jeff Parvin (Brigham and Women's Hospital and Harvard Medical School, Boston) presented evidence for a role of BRCA1 in ...
首页/癌基因/BRCA2/ LOSS-OF-FUNCTION BRCA1和BRCA2基因的遗传突变会增加患乳腺癌或卵巢癌的终生风险。BRCA1和BRCA2都参与了基因组稳定性的维持,特别是双链DNA修复的同源重组途径。BRCA2蛋白含有一个70 a a基序的几个拷贝,称为BRC基序,这些基序介导了与在DNA修复中起作用的RAD51重组酶的结合。BRCA2被认为是肿...
Cancer ResearchTwo of the most mysterious actors in cancer genetics may finally be sharing their secrets: the breast cancer susceptibility genes BRCA1 and BRCA2 . The genes, which cause cancer in up to 80% of women who carry mutated forms, had been thought to be tumor suppressors, which nor...
The BRCA1 protein, a hereditary breast and ovarian cancer-causing gene product, is known as a multifunctional protein that performs various functions in cells. It is well known, along with BRCA 2, to cause hereditary breast and ovarian cancer, but here we will specifically focus on BRCA1. We...
Several investigators have used the Brier index to measure the predictive accuracy of a set of medical judgments; the Brier scores of different raters who ... DA Redelmeier,DA Bloch,DH Hickam - 《Journal of Clinical Epidemiology》 被引量: 192发表: 1991年 BRCA1 and BRCA2 mutation predictions...
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RAD51 up-regulation bypasses BRCA1 function and is a common feature of BRCA1-deficient brea... Besides GIPC3, another GIPC family member, GIPC1 can also rescue BRCA2 loss-induced lethality in mESCs. Oncomine analysis showed Gipc2 mRNA up-regulation in BRCA1 deficient human breast tumors, ...
The BRCA1 gene encodes a tumor suppressor that has been implicated in hereditary forms of breast and ovarian cancer. During S phase of the cell cycle, BRCA1 polypeptides are found in discrete nuclear bodies ('BRCA1 nuclear dots') together with HsRad51, a human homolog of the E. coli recA...
BRCA1,a tumor suppressor,enhances the fidelity of NHEJ-mediated DSB repair and prevents mutagenic deletional end-joining through interaction with canonical NHEJ machinery during Gl.BRCAl binds and stabilizes Ku80 at DSBs through its Nterminal region,promotes precise DSB rejoining,and increases ...
Homologous Recombination (HR) is a high-fidelity process with a range of biologic functions from generation of genetic diversity to repair of DNA double-strand breaks (DSBs). In mammalian cells, BRCA2 facilitates the polymerization of RAD51 onto ssDNA to form a presynaptic nucleoprotein filament. ...