(ALDH) is the rate-limitingenzymein clearing acetaldehyde from the body. The clinical relevance ofALDHin skeletal function has been established by the discovery ofsingle nucleotide polymorphism, SNP (rs671) in theALDH2gene giving rise to an inactive form of the enzyme (ALDH2*2) that causes ...
A phenylalanine dehydrogenase having a substrate specificity for L-methionine can be produced by an evolutionary molecular engineering approach to provide a function-modified amino acid dehydrogenase suitable for enzymatic fluorometry of methionine. It becomes possible to provide a method for the analysis ...
(1997) Function of coenzyme F420-dependent NADP reductase in methanogenic archaea containing an NADP- dependent alcohol dehydrogenase, Arch. Microbiol. 168, 396±402.Berk, H. & Thauer, R. K. (1997). Function of coenzyme F,,,- dependent NADP reductase in methanogenic archaea containing an NADP...
Structure-function relationships in NDP-sugar active SDR enzymes: Fingerprints for functional annotation and enzyme engineering Biotechnology Advances Journal2021, Biotechnology Advances Matthieu Da Costa, ... Koen Beerens Abstract Short-chain Dehydrogenase/Reductase enzymes that are active on nucleotide ...
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function in zebrafish results in increased concentrations of D-lactate. D-lactate levels are rescued by wildtypeLDHDbut not by patients’ variantLDHD, confirming these variants’ loss-of-function effect. This work provides the first in vivo evidence that LDHD is responsible for human D-lactate ...
RDH12 codes for a member of the family of short-chain alcohol dehydrogenases/reductases proposed to function in the visual cycle that supplies the chromophore 11-cis retinal to photoreceptor cells. Mutations in RDH12 cause severe and progressive childhood onset autosomal-recessive retinal dystrophy, ...
We use essential cookies to make sure the site can function. We also use optional cookies for advertising, personalisation of content, usage analysis, and social media. By accepting optional cookies, you consent to the processing of your personal data - including transfers to third parties. Some...
Adipose Tissue Macrophages Function As Antigen-Presenting Cells and Regulate Adipose Tissue CD4+ T Cells in Mice The proinflammatory activation of leukocytes in adipose tissue contributes to metabolic disease. How crosstalk between immune cells initiates and sustains ... DL Morris,KW Cho,DelProposto, ...
[98–100]. The main function of G-6-PD is to provide sufficient NADPH to maintain redoxhomeostasis[101]. In addition, G-6-PD can also serve as anangiogenic factorto promoteangiogenesis, provide nutrition for tumour cells, and promote tumour cell growth[101]. It has been reported t...