et al. Itaconate links inhibition of succinate dehydrogenase with macrophage metabolic remodeling and regulation of inflammation. Cell Metab. 24, 158–166 (2016). Article CAS PubMed PubMed Central Google Scholar Cordes, T. et al. Immunoresponsive gene 1 and itaconate inhibit succinate dehydrogenase...
Cancer cells prefer aerobic glycolysis over OXPHOS, even in the presence of sufficient oxygen for energy metabolism [167] due to increased glucose uptake and glycolytic flux but reduced activity of the pyruvate dehydrogenase enzyme, which results in reduced pyruvate to acetyl CoA [168]. However, re...
A number of crop wild relatives can tolerate extreme stress to a degree outside the range observed in their domesticated relatives. However, it is unclear whether or how the molecular mechanisms employed by these species can be translated to domesticated crops. Paspalum (Paspalum vaginatum) is a ...
Blombach B, Schreiner ME, Moch M, Oldiges M, Eikmanns BJ (2007) Effect of pyruvate dehydrogenase complex deficiency on l-lysine production with Corynebacterium glutamicum. Appl Microbiol Biotechnol 76: 615–623 PubMed CAS Google Scholar Sindelar G, Wendisch VF (2007) Improving lysine productio...
Enzymes that require molybdenum for activity include nitrate reductase, xanthine dehydrogenase, aldehyde oxidase and sulfite oxidase.Loss of Mo-dependent enzyme activity (directly or indirectly through low internal molybdenum levels) impacts upon plant development, in particular, those processes involving ...
In the brain, the 5α-reductase converting testosterone (T) is present both in neurons and in glial cells, even if it prevails in neurons; the 3α-hydroxysteroid-dehydrogenase (3α-HSD), the enzyme converting dihydrotestosterone (DHT) into 3α-diol, is particularly concentrated in type 1 ast...
Glutamate dehydrogenase(GDH) is present mainly in mitochondria in higher plants and catalyses both the amination of a-oxoglutamate, with NADH as the electron donor, and the deamination of glutamate to ammonia and a-oxoglutamate, with NAD+ as the electron receptor. The NAD (H)-GDH, with a ...
et al. Alternative biotransformation of retinal to retinoic acid or retinol by an aldehyde dehydrogenase from Bacillus cereus. Appl. Environ. Microbiol. 82, 3940–3946 (2016). Article CAS PubMed PubMed Central Google Scholar Grizotte-Lake, M. et al. Gut commensals suppress epithelial cell ...
Endothelial cells (ECs) are highly glycolytic, but whether they generate glycolytic intermediates via gluconeogenesis (GNG) in glucose-deprived conditions remains unknown. Here, we report that glucose-deprived ECs upregulate the GNG enzyme PCK2 and rely
Pterostilbene also protects the liver from injury by reducing liver markers including aspartate aminotransferase (AST), alanine transaminase (ALT), lactate dehydrogenase (LDH), and alkaline phosphatase (ALP). Pterostilbene has also been shown to increase apoptotic activity by significantly increasing the ...