Activation of pyruvate dehydrogenase improves heart function and metabolism after hemorrhagic shock. J Mol Cell Cardiol 29: 2465-2474, 1997.Kline, J.A., et al., Activation of pyruvate dehydrogenase improves heart function and metabolism after hemorrhagic shock, J. Mol. Cell Cardiol., 29:2465-...
Uibo R, MacKay IR, Rowley M, Humphries P, Armstrong JMcD, McNeilage J: Inhibition of enzyme function by human autoantibodies to an autoantigen pyruvate dehydrogenase E2: Different epitope for spontaneous human and induced rabbit autoantibodies. Clin Exp Immunol 80: 19–24, 1990...
Pyruvate Dehydrogenase Complex Deficiency PDH is a complex of three primary enzymes— plus a phosphatase, a kinase, and at least one other element of less known function—that combine as a multimer with a very large molecular weight and a number of copies of each enzyme. The first enzymati...
Meldonium had no significant effect on blood glucose concentrations or on baseline cardiac function. However, hyperpolarized magnetic resonance revealed that meldonium treatment elevated pyruvate dehydrogenase flux by 3.1-fold and 1.2-fold in diabetic and control animals, respectively, suggesting an increase...
PDH activity is tightly regulated through reversible phosphorylation on the E1 subunit, which is modulated by the relative activities of pyruvate dehydrogenase kinases (PDK) and pyruvate dehydrogenase phosphatase. This intricate regulatory mechanism enables PDH to coordinate glucose oxidation, thereby maintaini...
Pyruvate dehydrogenase (PDH) is the gatekeeper enzyme of the tricarboxylic acid (TCA) cycle. Here we show that the deglycase DJ-1 (encoded by PARK7, a key familial Parkinson’s disease gene) is a pacemaker regulating PDH activity in CD4+ regulatory T cells (Treg cells). DJ-1 binds to ...
ab110174 – Pyruvate dehydrogenase (PDH) Profiling ELISA Kit Instructions for Use For the measurement of Pyruvate dehydrogenase (PDH) in Human, bovine, mouse, and rat whole tissue or cell lysate samples.This product is for research use only and is not intended for diagnostic use.Version 1 ...
FOXO1-mediated upregu- lation of pyruvate dehydrogenase kinase-4 (PDK4) decreases glucose oxidation and impairs right ventricular function in pulmonary hypertension: therapeutic benefits of dichloroacetate. J Mol Med (Berl) 2013b;91:333-46.
Is the MPC a viable therapeutic drug target for these disorders? Given the critical node the MPC inhabits within cellular metabolism, changes in MPC function may play a prominent role in metabolic disease. Pyruvate dehydrogenase After passage through the MPC, pyruvate has several potential fates wit...
components of the pyruvate dehydrogenase complex (PDH). PDH is a mitochondrial complex comprised of three catalytic subunits (E1, pyruvate decarboxylase; E2, dihydrolipoyllysine acetyltransferase [DLAT]; E3, dihydrolipoyl dehydrogenase), a structural subunit (PDH-binding component X [PDHX]) and ...