2.1Pyruvate dehydrogenase complex (PDC) PDC is a multi-enzyme complex located in themitochondrial matrixwhich connects the aerobicoxidationof glucose with theTCA cycleandOXPHOS. Mostly, PDH kinase inactivates PDC by phosphorylation of PDH atSerine293 and PDH phosphatase dephosphorylates PDH to r...
The mitochondrial pyruvate dehydrogenase complex constitutes one of the central pillars of cell metabolism, linking two major catabolic pathways: glycolysis and the citric acid cycle (CAC). Pyruvate carboxylase is another mitochondrial enzyme that catalyzes the conversion of pyruvate to oxaloacetate, a ...
Pyruvate dehydrogenase (PDH) complex is a mitochondrial matrix enzyme that serves a critical role in the conversion of anaerobic to aerobic cerebral energy. The regulatory complexity of PDH, coupled with its significant influence in brain metabolism, underscores its susceptibility to, and significance in...
1 976. Activity of the pyruvate dehydrogenase complex in the mammary gland of normal and diabetic rats. Diabeto{ogia 1 2: 1 49-54Kankel K F,Reinauer H.Activity of pyruvate dehydrogenase complex in the mammary gland of normal and diabetic rats. Diabetologia . 1976...
The increase in 2-phosphoglycerate and phosphoenolpyruvate levels in the CCI-EP group could be partly explained due to a direct metabolism of EP into acetyl-CoA in the mitochondrial matrix by the pyruvate dehydrogenase complex, subsequently entering the citric acid cycle [68]. This process may help...
N, Petrova-Benedict R, Federico A, Fois A, Cole DEC, Roberteson E, Robinson BH 1995 Mutations in the X-linked E1␣ subunit of pyruvate dehydro- genase: exon skipping, insertion of duplicate sequence, and missense mutations leading to the deficiency of the pyruvate dehydrogenase complex. Am...
Downregulating active pyruvate dehydrogenase (PDH) complex activity by overexpressing rat PDH kinase 2 (PDK2) in mouse hearts 来自 Semantic Scholar 喜欢 0 阅读量: 17 作者:T Vary,G Defter,L Shantz,M Mcnitt DOI: 10.1016/S0022-2828(01)90690-X ...
Proteins within the pyruvate dehydrogenase complex were downregulated, while pyruvate kinase isozymes R/L, involved in synthesizing pyruvate, were upregulated. Together these data indicate a clear metabolic effect of ADIPINT on lipid and energy metabolism, including the regulation of key components in ...
keeping a correct caloric intake This effect might be explained by the fact that during acute infections, it is necessary to increase the energy metabol ism This could be more complex in patients with pyruvate dehydrogenase deficiency given the specific deficits associated with the disease In ...
Because the pyruvate dehydrogenase complex (PDC) contributes so powerfully to the control of glucose oxidation, we set out to test the hypothesis that the function of PDC is impaired in cardiac hypertrophy. In this review we describe evidence indicating that the alterations in glucose metabolism in...