Our results are validated by examining LDHA expression, at the mRNA level, in the independent data set of clear cell renal cell carcinoma cases from The Cancer Genome Atlas databases which also shows that higher lactate dehydrogenase A expression is associated with significantly shorter overall ...
Biological effects of the dihydroorotate dehydrogenase inhibitor polyporic acid, a toxic constituent of the mushroom Hapalopilus rutilans , in rats and ... Inhibitors of dihydroorotate dehydrogenase (DHO-DH), such as brequinar or leflunomide, have been intensively tested for their antitumour and ...
(2009). The lactate dehydrogenase-elevating virus capsid protein is a nuclear-cytoplasmic protein. Arch. Virol. 154, 1071-1080. doi: 10.1007/s00705-009-0410-0The lactate dehydrogenase-elevating virus capsid protein is a nuclear–cytoplasmic protein[J] . Hakimeh Mohammadi,Shayan Sharif,Raymond R...
Besides clinical characteristics, easy-accessible laboratory markers could be of value to refine risk stratification in peripheral artery disease. In the current study, we investigated whether α-hydroxybutyrate dehydrogenase (HBDH) is associated with at
No treatment (a); buffer (b); succinate dehydrogenase enzyme produced and purified by the same process and collected in the same fractions as Tupanvirus beta-lactamase TupBlac, used as negative control (c); Tupanvirus beta-lactamase TupBlac (d). Full size image The recombinant protein AUL...
Lactate dehydrogenase B (LDHB) Tetrameric LDH includes LDHA and LDHB, two subunits that are encoded by independent genes. LDHA catalyzes the conversion of pyruvate to lactate and regenerates NAD+, whereas LDHB catalyzes the opposite reaction and converts lactate to pyruvate along with the formation...
(NiFe)-hydrogenase Group 1b, large subunit; fccB: flavocytochrome c sulfide dehydrogenase; sqr: sulfide:quinone reductase; soxA, soxB, soxC: sulfur oxidation proteins; sorA: sulfite dehydrogenase; psrA: polysulfide reductase, subunit I; qoxB: cytochrome c oxidase, caa3-type, subunit I; ...
Molecular Cancer 2014, 13:101 http://www.molecular-cancer.com/content/13/1/101 RESEARCH Open Access Lactate Dehydrogenase A is a potential prognostic marker in clear cell renal cell carcinoma Hala Girgis1,2, Olena Masui3, Nicole MA White1,2,4, Andreas Scorilas5, Fabio Rotondo1,2, Annett...
Furthermore, inhibition of the cytosolic NAD+ recycling enzyme lactate dehydrogenase A (LDHA), enhanced the effects of the NADH shuttle inhibitors. In a 3D model using Group 3 human cerebellar organoids, tumor cells also underwent apoptosis upon treatment with NADH shuttle inhibitors. Our study ...
GRP75, mitochondrial stress-70 protein; LONM, mitochondrial Lon protease; CH60, mitochondrial 60 kDa heat shock protein; AL1B1, mitochondrial aldehyde dehydrogenase X; ALAT2, alanine aminotransferase 2; CP237, cytochrome P450 2C37; ACOT2, mitochondrial acyl-coenzyme A thioesterase 2; AOFA, ...