govern theN-glycan specificities of EndoS26,27and EndoS228. However, the mechanism by which these enzymes specifically process theN-glycan on the Fc region of IgG antibodies but no other glycoproteins has not yet been described. Here, we present the cryoEM structure of EndoS in complex with ...
Fig. 1: Overall structure of EndoS in complex with the Fc region. aEndoS, SpeB and IdeS are secreted enzymes fromS. pyogenesthat can act on IgG antibodies. SpeB and IdeS are proteases that hydrolyze the flexible hinge region between residues 220 to 248 of the IgG antibody96,97,98. En...
govern theN-glycan specificities of EndoS26,27and EndoS228. However, the mechanism by which these enzymes specifically process theN-glycan on the Fc region of IgG antibodies but no other glycoproteins has not yet been described. Here, we present the cryoEM structure of EndoS in complex with ...