Innovations in microscopy and image analysis have enabled the measurement of thousands of morphological traits from a single cell, constructing morphology based ‘profiles’. Cell Painting, for example, leverages multiplexed dyes to enable the measurement of traits across many cellular compartments and org...
Current inflammatory bowel disease (IBD) therapies are ineffective in a high proportion of patients. Combining bulk and single-cell transcriptomics, quantitative histopathology and in situ localization across three cohorts of patients with IBD (total n