Pleiotropy (biology definition):the condition of having multiple effects. In genetics, it refers to a single gene controlling or influencing multiple (and possibly unrelated) phenotypic traits. Is hair color a
Long-term selection experiments are a powerful tool to understand the genetic background of complex traits. The longest of such experiments has been conducted in the Research Institute for Farm Animal Biology (FBN), generating extreme mouse lines with increased fertility, body mass, protein mass an...
Definition of traits We used adiposity measures directly provided by the UK Biobank, including VAT (data field 22407), WFM (data field 23100) and impedance of whole body (data field 23106). WHR was calculated by dividing the waist-to-hip circumference. MRI-derived PDFF and liver iron correct...
individuals were scanned using a Siemens 1.5T Magnetom Aera. Two sequences were then used for data acquisition, a multiecho-spoiled gradient-echo and a modified look locker inversion sequence (ShMOLLI) for PDFF and cT1, respectively45. The definition of binary traits can be found in Supplementa...
Based on this definition, AUC can be approximated by a function of the GWAS summary statistics. This method can tune the parameters of a PRS model with summary statistics from another GWAS. To maximize the power of identifying loci associated with common diseases, some large consortia have ...
(MC) confidence intervals for the various fit functions as described in Section “Methods”. The asymptotic predictions for each trait can be averaged, incorporating the confidence intervals, and the results are given in Table2. Further projection plots for the remaining traits can be found in ...
clumping and thresholding C+T complex traits UK Biobank stacking Introduction The ability to predict disease risk accurately is a principal aim of modern precision medicine. As more population-scale genetic datasets become available, polygenic risk scores (PRS) are expected to become more accurate and...
Answer to: Personality traits and intelligence are: a) polygenic, the result of many genes. b) discrete phenotypes. c) revealed by family...
(MC) confidence intervals for the various fit functions as described in Section “Methods”. The asymptotic predictions for each trait can be averaged, incorporating the confidence intervals, and the results are given in Table2. Further projection plots for the remaining traits can be found in ...
Twitter Google Share on Facebook polygenic Thesaurus Medical Encyclopedia Wikipedia Related to polygenic:polygenic disease,polygenic disorder,Polygenic traits pol·y·gen·ic (pŏl′ē-jĕn′ĭk) adj. 1.Of, relating to, or determined by polygenes:polygenic inheritance. ...