What is a polygenic trait? Learn the definition of polygenic traits and about polygenic characteristics, polygenic selection, and polygenic traits...
polygenic Thesaurus Medical Encyclopedia Wikipedia Related to polygenic:polygenic disease,polygenic disorder,Polygenic traits pol·y·gen·ic (pŏl′ē-jĕn′ĭk) adj. 1.Of, relating to, or determined by polygenes:polygenic inheritance.
Pleiotropy (biology definition):the condition of having multiple effects. In genetics, it refers to a single gene controlling or influencing multiple (and possibly unrelated) phenotypic traits. Is hair color a polygenic trait? Human skin, hair, and eye color are alsopolygenic traitsbecause they are...
Answer to: Personality traits and intelligence are: a) polygenic, the result of many genes. b) discrete phenotypes. c) revealed by family...
This has the following implications for complex traits that are roughly additive in genetic architecture: 1. The sibling distribution of (additive) polygenic scores (PGS) for such traits is centered at the parental midpoint 2. The sibling genetic variance is roughly half that found in the ...
LDpred2 was further proposed to increase computational efficiency and provide more stable results than LDpred in dealing with long-range LD regions and traits of sparse genetic architecture. To allow more general effect size distributions, sBayesR performs Bayesian posterior inference based on a ...
We can use the previous definition but for the training case with the maximum number of equal cases and controls. The same caveats from definition 1. apply. 3. Because we expect traits not to be 100% heritable, we expect metrics to asymptotically approach a limit value. We can look at re...
(87,985 SNPs were included) while a substantially sparser model with 31 SNPs would yield better predictive performance for AD. These results showcased our method’s ability to adaptively choose the optimal tuning parameter for traits with different patterns of genetic architecture. These results also...
clumping and thresholding C+T complex traits UK Biobank stacking Introduction The ability to predict disease risk accurately is a principal aim of modern precision medicine. As more population-scale genetic datasets become available, polygenic risk scores (PRS) are expected to become more accurate and...
Note that the odds ratio for obesity is not reported here, as it will be published by the Genetic Investigation of ANthropometric Traits consortium (Smit et al., manuscript in preparation). ‘Number of SNPs’ represents the range of numbers or sites included in each score. ‘Age ranges for ...