What is a polygenic trait? Learn the definition of polygenic traits and about polygenic characteristics, polygenic selection, and polygenic traits...
polygenic Thesaurus Medical Encyclopedia Wikipedia Related to polygenic:polygenic disease,polygenic disorder,Polygenic traits pol·y·gen·ic (pŏl′ē-jĕn′ĭk) adj. 1.Of, relating to, or determined by polygenes:polygenic inheritance.
Pleiotropy (biology definition):the condition of having multiple effects. In genetics, it refers to a single gene controlling or influencing multiple (and possibly unrelated) phenotypic traits. Is hair color a polygenic trait? Human skin, hair, and eye color are alsopolygenic traitsbecause they are...
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits. PLoS Genet. 2011;7: e1001324. Article CAS PubMed PubMed Central Google Scholar Parisinos CA, Wilman HR, Thomas EL, Kelly M, Nicholls RC, McGo...
LDpred2 was further proposed to increase computational efficiency and provide more stable results than LDpred in dealing with long-range LD regions and traits of sparse genetic architecture. To allow more general effect size distributions, sBayesR performs Bayesian posterior inference based on a ...
Note that the odds ratio for obesity is not reported here, as it will be published by the Genetic Investigation of ANthropometric Traits consortium (Smit et al., manuscript in preparation). ‘Number of SNPs’ represents the range of numbers or sites included in each score. ‘Age ranges for ...
be generated similarly, although for all 7 case-control traits it leads to 357 plots which can be difficult to interpret. An initial interpretation of these results is that at extreme values of PGS there are large increases in OR: for asthma, within ancestry testing (i.e. the sibling group...
clumping and thresholding C+T complex traits UK Biobank stacking Introduction The ability to predict disease risk accurately is a principal aim of modern precision medicine. As more population-scale genetic datasets become available, polygenic risk scores (PRS) are expected to become more accurate and...
We can use the previous definition but for the training case with the maximum number of equal cases and controls. The same caveats from definition 1. apply. 3. Because we expect traits not to be 100% heritable, we expect metrics to asymptotically approach a limit value. We can look at re...
Accumulating evidence from genome wide association studies (GWAS) suggests an abundance of shared genetic influences among complex human traits and disorders, such as mental disorders. Here we introduce a statistical tool, MiXeR, which quantifies polygen