Google Share on Facebook quantitative trait locus (redirected fromPolygenic traits) quantitative trait locus [‚kwänt·ə‚tād·iv ¦trāt ′lō·kəs] (genetics) The location of a gene that affects a quantitative trait. McGraw-Hill Dictionary of Scientific & Technical Terms, 6E, Copy...
An essential question in evolutionary biology is whether shifts in a set of polygenic behaviors share a genetic basis across species. Such a behavioral shift is seen in the cave-dwelling Mexican tetra, Astyanax mexicanus. Relative to surface-dwelling conspecifics, cavefish do not school (asocial)...
It is noteworthy that we also detected an interaction between GO:1902991 (regulation of amyloid precursor protein (APP) catabolic process) and the gene expression level in microglia (q = 1.4 × 10−3; Supplementary Table 18). Even though these data suggest a functional relationship ...
R. Genetic correlations of polygenic disease traits: from theory to practice. Nat. Rev. Genet. 20, 567–581 (2019). This review defines genetic correlations, summarizes methods, and discusses their interpretation and uses with respect to human health and disease. Article PubMed CAS Google ...
Web-based, participant-driven studies yield novel genetic associations for common traits. PLoS Genet. 2010;6:e1000993. doi:10.1371/journal.pgen.1000993Google Scholar 41. Ramasamy A, Trabzuni D, Guelfi S, et al; UK Brain Expression Consortium; North American Brain Expression ...
Correlates of Aggression in Personality Disorders: an Update Background Emotion dysregulation (ED) is defined as patterns of emotional experience or expression that interfere with goal-directed behaviour [1]. ED is recognized as a core etiological and maintenance mechanism of borderline personality disord...
Schizophrenia is a severe psychiatric disorder with considerable morbidity and mortality. Although the past two decades have seen limited improvement in the treatment of schizophrenia, research into the genetic causes of this condition has made important
LD score regression distinguishes confounding from polygenicity in genome-wide association studies. Nat Genet. 2015;47(3):291-295. PubMedGoogle ScholarCrossref 41. Ning Z, Pawitan Y, Shen X. High-definition likelihood inference of genetic correlations across human complex traits...
K. An expanded view of complex traits: from polygenic to omnigenic. Cell 169, 1177–1186 (2017). This is a recent description and expansion of Fisher's infinitesimal model. Article CAS PubMed PubMed Central Google Scholar Fisher, R. A. The correlation between relatives on the supposition ...
Previous research suggests an association of loneliness and social isolation (LNL-ISO) with schizophrenia. Here, we demonstrate a LNL-ISO polygenic score contribution to schizophrenia risk in an independent case-control sample (N = 3,488). We then subset schizophrenia predisposing variation based...