Polygenic scores capture only part of the genetic liability to a disease or trait, but the proportion explained increases with larger GWAS sample sizes and with improvements in polygenic scoring methodology. For example, individuals in the top 8% of cardiovascular disease (CAD) polygenic scores have...
A joint (multi-phenotype) analysis of educational attainment and three related cognitive phenotypes generates polygenic scores that explain 11–13% of the variance in educational attainment and 7–10% of the variance in cognitive performance. This prediction accuracy substantially increases the utility ...
We suggest that restoration of male fertility is probably best viewed as a quantitative trait controlled by many loci. We develop a threshold model that accommodates an underlying polygenic trait, which is resolved at the phenotypic level in discrete sexual morphs. We use this model to reanalyse...
The presence of phenomena analogous to phase transition in Statistical Mechanics has been suggested in the evolution of a polygenic trait under stabilizing selection, mutation and genetic drift. By using numerical simulations of a model system, we analyze the evolution of a population of N diploid ...
We suggest that this is due to resilience of polygenic QTs to changes in allele frequency or lack of selection for hybrid niche divergence in geographic isolation. While S. squalidus is intermediate or parental-like for most QTs, some trangressively distinct traits were observed, which might ...
Summary data on ADHD, ASD, TS, Fractures and Osteoporosis is available on supplementary material.References Jain P, Miller-Fleming T, Topaloudi A, Yu D, Drineas P, Georgitsi M, Yang Z, Rizzo R, Müller-Vahl KR, Tumer Z et al. Polygenic risk score-based phenome-wide association study ...
These studies led to the emergence of the ‘polygenic hypothesis,’ which posits that an indefinite number of genes are involved in every trait, each having a small contribution (Barton et al., 2017). Notably, the contribution of many genes, which in most cases is marginal, becomes important...
Multi-SNP, multi-trait regression https://github.com/ashlee1031/BERRRI regioneR: permutation testing for association between genomic region and phenotype http://bioconductor.org/packages/release/bioc/html/regioneR.html https://sites.google.com/site/honglee0707/mtg2 Use local gene networks to improv...
We found no evidence that intermediate frequency alleles were important to quantitative trait variation underlying mating success, which might have been expected under alternative models for the maintenance of genetic variation. For example, sexual conflict36,37,38 is well documented among drosophilids39...
is associated with two genes that are also known to affect human speech, Neurexin-1 and Coenzyme Q8A. Models leveraging ancestry reveal these candidate loci also impact rhythmic stability, a trait linked with motor performance which is an indicator of quality. Character displacement in rhythmic ...