A primary goal of polygenic scores, which aggregate the effects of thousands of trait-associated genetic variants discovered in GWAS, is to estimate individual-specific genetic propensities. This is typically achieved using a single polygenic score, but here we use an approach to increase predictive ...
Summary of publicly available PGS.ATop 25 traits/diseases which have the greatest number of PGS in the PGS Catalog.BDistribution of total sample size (sum) used to develop each PGS (either as a GWAS or in score development).CAncestry composition of sample sets used for PGS development and e...
The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear...
Naturally, the HSV primarily spreads through direct contact, predominantly in the perioral region. It typically manifests as a relatively benign ailment; however, in rare instances, it can invade the central nervous system and cornea, precipitating grave consequences such as encephalitis and visual imp...
168 of 182 traits analyzed showed sig- nificant differences between ethnic groups (Bonferroni cor- rected analysis of variance P < 0.01; Supplementary Table S3 online), reinforcing the widely held notion that an individual's polygenic scores can be rigorously interpreted only in the con- text of...
B, D Simulation results for binary traits with balanced case–control ratio. Proportion of causal variants is 0.1% in A and B, and 20% in C and D. The heritability is set to be 0.5 in all panels. Models that do not require fine-tuning are shown on the left side of each panel. Y...
GWAS summary statistics data, unlike individual-level genetic data, are often publicly available for many traits and diseases. It typically contains results from univariate association test statistics on a variant-per-row format. In this study, GWAS summary statistics data from two studies were used...
The correlation of family means was estimated to determine if the traits should be considered as biologically independent. This revealed the traits are only moderately correlated (r2 = 0.76), prompting their subsequent treatment in GWAS as independent. Fig. 1 Relationship of sex and weight for...
The most common concern present in the news coverage was the potential use of PGT-P for non-medical traits, such as hair or eye colour. This was often described as a slippery slope towards designer babies (Q1, Additional file 1: Table S2). This "slippery slope" was mentioned in 50 out...
PRS for intelligence had a similar impact, whereas PRS for schizophrenia did not affect these traits. We conclude that the majority of working-age individuals carrying high-risk CNVs without SNPD diagnosis have a modest impact on morbidity and mortality, as well as the limited impact on income ...