Polygenic genome editing in human embryos and germ cells is predicted to become feasible in the next three decades. Several recent books and academic papers have outlined the ethical concerns raised by germline genome editing and the opportunities that i
but still significant. Population genetics theory implies that the standard deviation in sibling PGS is2smaller than for the general population. We demonstrate this empirically using UKB and IVF clinic data, and illustrate that variation in important traits and disease risks among siblings is substantial...
The increasing proportion of variance in human complex traits explained by polygenic scores, along with progress in preimplantation genetic diagnosis, suggests the possibility of screening embryos for traits such as height or cognitive ability. However, the expected outcomes of embryo screening are unclear...
in the context of human traits, might be considered mutagenic and, on average, likely deleterious. This places constraints on the clinical use of gene editing, especially genome editing in germ cells or embryos. We modelled the deleterious effects of off-target edits by assuming that they have ...
Cry toxins we tested, as well as growth on the control treatments were quantitative genetic traits (SI Results). Based on our experimental design, we predicted that recombination in the F1 generation should reduce correlations between growth on control and toxin-incorporated diet within individual ...
Naturally, the HSV primarily spreads through direct contact, predominantly in the perioral region. It typically manifests as a relatively benign ailment; however, in rare instances, it can invade the central nervous system and cornea, precipitating grave consequences such as encephalitis and visual imp...
We then examined the impact of the high and non-high polygenic burden of the five polygenic risk score traits on the patient’s primary kidney disease. Statistically significant differences were observed in the age at kidney failure and decreased eGFR polygenic risk score burden between glomerulonephr...
The correlation of family means was estimated to determine if the traits should be considered as biologically independent. This revealed the traits are only moderately correlated (r2 = 0.76), prompting their subsequent treatment in GWAS as independent. Fig. 1 Relationship of sex and weight for...
PGS development results in a set of variants and weights that can be used to estimate genetic predisposition; however, other steps are necessary to measure PGS in individuals and return an interpretable test result [59]. Typically PGS have been developed in cohorts of genotyped individuals using ...
associations. Loci in bold are shared among both traits irrespective of the adiposity adjustment. Only loci with a genome-wide significantP <5 × 10−8calculated by a whole-genome regression model (Methods) are shown.Pvalues were two-sided and not corrected for multiple testing among ...