Natural killer (NK) cells and T lymphocytes are derived from a common progenitor cell ( 1 ). This common origin is reflected in mature cells of both lineages: T and NK cells express cell surface receptors utilizing shared signaling chains that couple to similar signal transduction pathways. ...
KILLER cellsIntroduction: We have previously shown that Angioimmunoblastic T‐cell Lymphoma (AITL) overexpresses CXCL12 and that patients (pts) with CXCL12‐overexpressing T‐lymphomas, including AITL, experience a high rate of response to the farnesyltransferase inhibitor tipifarnib (50% ORR, 90% ...
Immune checkpoint inhibitors enhance cytotoxicity of cytokine-induced killer cells against human myeloid leukaemic blasts Blockade of KIR, LAG-3, PD-1 and TIM-3 but not CTLA-4 resulted in remarkable increase in killing against these targets, even in those with poor ... LP Su,YC Linn - 《Can...
What is the role of active killer cells in cell mediated immunity? What are chromaffin cells? What do chromaffin cells do? Viruses are not made up of cells. According to cell theory, this means what? What are germ cells? What does 80% confluency mean in a cell? What is the role of ...
DC, dendritic cell; Fib., fibroblast; GC, germinal center; ILC, innate lymphoid cell; Myofib., myofibroblast/smooth muscle; NK, natural killer. Full size image When all snRNA-seq cells (Fig. 1b) and scATAC-seq cells (Fig. 1c) are projected into low-dimensional subspaces, stromal and ...
Charoentong has studied a variety of human immune cell subtypes, such as activated DC, activated CD8 T cells, natural killer T cells, macrophages, regulatory T cells, etc. (Table S2). Each type of immune cell was marked by using Charoentong’s gene set. Next, we calculated the enrichment...
The collective gene sets (Tables S3 and S4) were enriched in immune (T cell, natural killer [NK] cell, neutrophil) signaling, intracellular signaling (JAK/STAT), and cytokine and chemokine signaling pathways (nominal p < 0.05 and q < 0.3; Figure 1B). Furthermore, a subset of the DEGs...
Despite recovery of myelopoiesis, most patients had profound defects in T, B, and natural killer (NK) cell numbers that failed to recover at any point during therapy. Conclusion Autologous tumor vaccination at a time of ALL relapse is not feasible. Alternative strategies for immunotherapy of ALL...
Despite recovery of myelopoiesis, most patients had profound defects in T, B, and natural killer (NK) cell numbers that failed to recover at any point during therapy. Autologous tumor vaccination at a time of ALL relapse is not feasible. Alternative strategies for immunotherapy of ALL may ...
and proliferating cell subsets. Other immune components including monocytes, macrophages, dendritic cells including classical (cDC1 and cDC2) and plasmacytoid (pDC), natural killer (NK) cells, NKT cells and mast cells were also identified (Fig.1f–h). We calculated the fraction of tumor cells ...