Bronchoalveolar lavage invariant natural killer T cells are not increased in asthma. J Allergy Clin Immunol 119:1274–1276.Umetsu DT, DeKruyff RH. A role for natural killer T cells in asthma. Nat Rev Immunol 2006;6:953-8.KugathasanMutalithas, JoanneCroudace, CristinaGuillen, SalmanSiddiqui, ...
Natural killer T (NKT) cells influence diverse immune responses, combining features of both the innate and adaptive immune systems. This Review examines the unique role of invariant NKT cells (which have an invariant T-cell-receptor α-chain) in the resp
We have previously demonstrated that liver sinusoidal endothelial cells (LSECs) that endocytose portally injected allogeneic cells exert immunosuppressive effects on T cells with indirect allospecificity. In this study, we have demonstrated that invariant natural killer T cells plays a significant role ...
ROLE FOR HEDGEHOG PATHWAY IN REGULATING GROWTH AND FUNCTION OF INVARIANT NATURAL KILLER T CELLS 来自 国家科技图书文献中心 喜欢 0 阅读量: 38 作者:WK Syn,Rafal P Witek,Stuart M Curbishley,Y Jung,Steve S Choi,B Enrich,A Omenetti,Kolade M Agboola,Caitlin M Fearing,H Tilg ...
Purpose To determine the role of T cells and natural killer (NK) cells in mediating corneal xenograft rejection of a pig-to-mouse model. Methods Pig corneas were orthotopically transplanted to C57BL/6, Balb/c-nu and CB.17 SCID mice with or without NK depletion. NK cells were depleted ...
Killer T cells (cytotoxic T lymphocytes, CTLs) maintain immune homoeostasis by eliminating virus-infected and cancerous cells. CTLs achieve this by forming an immunological synapse with their targets and secreting a pore-forming protein (perforin) and pr
Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development. Here we found that the H3K27me3 histone demethylase UTX was an essential cell...
gamma delta-T cells represent a small population of immune cells, but play an indispensable role in host defenses against exogenous pathogens, immune surve... J Zheng,Y Liu,Lau, Yu-Lung,... - 《中国免疫学杂志(英文版)》 被引量: 97发表: 2013年 Natural T, gammadelta, and NK cells in ...
Role of Natural Killer Cells in Psychosocial Stressor-induced Changes in Mouse Mammary Tumor Growth 1 We have shown that social housing conditions affect the growth rate of the androgen-responsive Shionogi mouse mammary tumor (SC115) and differentially stim... G. Rowse,Joanne,Weinberg,... 被引...
1. The high expression leels of GzmH in naie natural killer cells and its potent killing ability strongly support the role of the protease in triggering an alternatie cell-death pathway in innate immunity. GzmH在幼稚NK细胞中的高水平表达及其潜在的杀伤活性强有力地表明在天然免疫中这种蛋白酶可以激...