Recent studies have deciphered the developmental pathway of human MAIT and Vγ9Vδ2 γδ-T cells as well as murine iNKT cells, yet our understanding of human NKT cell development is limited. Here, we provide an update in our understanding of how NKT cells develop i...
Raising the NKT cell family. Nat. Immunol. 11, 197–206 (2005). 12. Sandberg, J.K., Stoddart, C.A., Brilot, F., Jordan, K.A. & Nixon, D.F. Development of innate CD4 þ alpha-chain variable gene segment 24 (Valpha24) natural killer T cells in the early human fetal thymus...
Invariant natural killer T (iNKT)-cell development is controlled by many polymorphic genes present in commonly used mouse inbred strains. Development of type 1 diabetes (T1D) in NOD mice partly results from their production of fewer iNKT... Tsaih,S-W,Presa,... - 《Genes & Immunity》 被引...
There is heterogeneity in invariant natural killer T (iNKT) cells based on the expression of CD4 and the IL-17 receptor B (IL- 17RB), a receptor for IL-25 which is a key factor in TH2 immunity. However, the development pathway and precise function of these iNKT cell subtypes remain un...
Killer T cell mediated apoptosis pathway What are killer T cells and what do killer T cells do? Killer T cells, also known as cytotoxic T lymphocytes (CTLs), are produced during cell-mediated immunity and are designed to remove body cells ...
(FDR < 0.05) specific to NK cells or shared with other immune cells; monocytes, neutrophils, CD4+and CD8+T cells.cEnrichment of shared causal loci between NK cell eQTL (total, left panel; NK cell-specific, right panel) and GWAS traits (n = 100). Traits are compared with the...
Clinical manufacturing of NK cell therapies Successful development of allogeneic off-the-shelf NK cell therapies requires the establishment of an adequate manufacturing workflow. Such a multi-step process, as described in Fig.3, starts with cell isolation from the starting material of choice, followed...
T-cell and natural killer cell development in thymectomized Xenopus Summary: The Xenopus early-thymectomy model system is used to investigate the extent to which the thymus controls T-cell development and to probe the evolution of natural killer (NK) ceils. Loss of T-cell function following ...
Summary: T-cell development is initiated when CD34+ pluripotent stem cells or their immediate progeny leave the bone marrow Co migrate to the thymus. Upon ... H Spits,B Blom,AC Jaleco,... - 《Immunological Reviews》 被引量: 336发表: 1998年 Cloning of Human T and Natural Killer Cells Sp...
Invariant natural killer T cells (iNKT cells) are innate-like lymphocytes that protect against infection, autoimmune disease and cancer. However, little is known about the epigenetic regulation of iNKT cell development. Here we found that the H3K27me3 histone demethylase UTX was an essential cell...