Purpose of review:T-cell/natural killer (T/NK)-cell lymphomas represent a group of poor-risk lymphoproliferative disorders that have only recently been recognized as distinct clinicopathologic entities. The average outcome with currently available therapy is substantially inferior to that of aggressive B...
Nils-Petter Rudqvist, in Methods in Cell Biology, 2023 1 Introduction T cells are the primary mediator of cytotoxicity in cancer immunotherapy. However, as the cancers evolve and progress, they may acquire abilities that allow them to escape T cell-based immunity. T cells recognize tumor cells...
These cells are defined by their ability to mobilize quickly into activated T cells to initiate a sufficient immune reaction in response to a previously encountered immune challenge. Natural killer T (NKT) cells (separate and distinct from natural killer cells, which are part of the innate immune...
Advani, "Extranodal natural killer/T- cell lymphoma: current concepts in biology and treatment biology and treatment," Leukemia and Lymphoma, vol. 50, no. 11, pp. 1773-1784, 2009.Kohrt H, Advani R: Extranodal natural killer/T-cell lymphoma: current concepts in biology and treatment. Leuk ...
Cytotoxic granules from killer cells: specificity of granules and insertion of channels of defined size into target membranes. J. Immunol. 135, 4245–4251 (1985). PubMed CAS Google Scholar Podack, E. R. & Konigsberg, P. J. Cytolytic T cell granules. Isolation, structural, biochemical, ...
asthma P Matangkasombut1,2, M Pichavant1, RH DeKruyff1 and DT Umetsu1 A crucial role has been suggested for invariant natural killer T cells (iNKT) in regulating the development of asthma, a complex and heterogeneous disease characterized by airway inflammation and airway hyperreactivity (AHR...
the inhibition of normal polyclonal immunoglobulin secretion results in humoral immune dysfunction. Activation receptors on the surface of cytotoxic T lymphocytes and natural killer (NK) cells are down-regulated, resulting in functional deficits [5,6]. At the same time, malignant plasma cells block ...
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Natural killer (NK) cells develop from the nonadherent cell component of NK long-term bone marrow (BM) cultures (NK-LTBMC). Because these nonadherent cells are depleted of mature NK cells and T cells, but appear to be enriched for NK precursors, they were used as a starting population ...
In vitro studies using a survivin inhibitor, terameprocol, led to a significant increase in apoptosis and decreased viability of tumor cells, thus presenting a potential therapeutic opportunity. 2.2.2. AURKA Aurora Kinase A (AURKA) is a serine/threonine kinase that contributes to the regulation ...