the mRNA transcription of these genes requires better stability to maintain their translation activity. The DEAD-box protein family is an ATP-dependent RNA helicase family involving a variety of RNA metabolic processes such as RNA secondary structure transformation, transcription...
DEAD-box家族蛋白是一类ATP依赖的RNA解旋酶,在RNA代谢的过程中发挥重要的作用.DEAD-box家族蛋白可通过调节癌基因和抑癌基因的表达及肿瘤相关信号通路等影响细胞的增殖,分化,凋亡,进而发挥促癌或抑癌的作用.%DEAD-box family protein is a kind of ATP dependent RNA helicase,which plays a critical role in RNA...
a family of ancient extraction 世系古老的家族,世家 16. The Family History of LI Chieftain of Tu Nationality 土族土司研究——土族李土司家族史 17. The Imagination and Narration of Ethnicity of "National Writer" of Dong; 侗族“民族作家”的族群想象及其叙事 18. Women s Poetry of the Bai,Zhu...
Translation initiation factor 4A is the prototype of the DEAD-box family of proteins. Actually, the DEAD-box protein family was discovered on the basis of conserved sequence motifs of eIF4A. Motif II (or Walker B motif) has the amino acids D-E-A-D (Asp-Glu-Ala-Asp), which gave the ...
RNA helicases of the DEAD box family are highly conserved enzymes with many roles in gene expression. Structural and mechanistic studies are uncovering the basis of their actions and have revealed roles not only in RNA unwinding but also in the remodelli
a substantial proportion of research focuses on the involvement of this protein family in tumors of the digestive system and its accessory organs. Through a thorough review of the literature and database analyses (TIMER2.0, GEPIA), it has been observed that DEAD-box helicase family proteins are ...
RNA helicases of the DEAD-box family are required for different cellular processes such as transcription, pre-mRNA processing, ribosome biogenesis, nuclear mRNA export, translation initiation, RNA turnover and organelle function. The structure of the core element, which contains all the conserved moti...
4) DEAD-box family DEAD-box家族 1. DEAD-box family proteins are a putative ATP-dependent RNA helicase, which form a widely dispersed family of proteins ranging from viruses to mammals, and are associated with nearly all RNA processes. DEAD-box家族蛋白是一类ATP依赖的RNA解旋酶,广泛存在于从...
Here we show that members of the large and highly abundant family of RNA-dependent DEAD-box ATPases (DDXs)3 are regulators of RNA-containing phase-separated organelles in prokaryotes and eukaryotes. Using in vitro reconstitution and in vivo experiments, we demonstrate that DDXs promote phase ...
Figure 1. Consensus sequence of the DEAD-box family. Residues identified in the structure of the Vasa protein to interact with ATP (red), RNA (blue) or involved in intra-protein interactions (green) are highlighted. Capital letters represent amino acids conserved at least 80%, lower case lett...