DEAD-box家族蛋白是一类ATP依赖的RNA解旋酶,在RNA代谢的过程中发挥重要的作用.DEAD-box家族蛋白可通过调节癌基因和抑癌基因的表达及肿瘤相关信号通路等影响细胞的增殖,分化,凋亡,进而发挥促癌或抑癌的作用.%DEAD-box family protein is a kind of ATP dependent RNA helicase,which plays a critical role in RNA...
1) DEAD-box family DEAD-box家族1. DEAD-box family proteins are a putative ATP-dependent RNA helicase, which form a widely dispersed family of proteins ranging from viruses to mammals, and are associated with nearly all RNA processes. DEAD-box家族蛋白是一类ATP依赖的RNA解旋酶,广泛存在于从细菌...
the mRNA transcription of these genes requires better stability to maintain their translation activity. The DEAD-box protein family is an ATP-dependent RNA helicase family involving a variety of RNA metabolic processes such as RNA secondary structure transformation, transcription...
mRNA biogenesis in the eukaryotic nucleus is a highly complex process. The numerous RNA processing steps are tightly coordinated to ensure that only fully processed transcripts are released from chromatin for export from the nucleus. Here, we present the hypothesis that fission yeast Dbp2, a ribonuc...
RNA helicases of the DEAD box family are highly conserved enzymes with many roles in gene expression. Structural and mechanistic studies are uncovering the basis of their actions and have revealed roles not only in RNA unwinding but also in the remodelli
The human RNA helicase DDX1 in the DEAD-box family plays an important role in RNA processing and has been associated with HIV-1 replication and tumour progression. Whereas previously described DEAD-box proteins have a structurally conserved core, DDX1 shows a unique structural feature: a large ...
DEAD-box RNA helicases comprise a family within helicase superfamily 2 and make up the largest group of RNA helicases. They are a profoundly conserved family of RNA-binding proteins, carrying a generic Asp–Glu–Ala–Asp (D–E–A–D) motif that gives the family its name. Members of the...
The Ded1 protein (Ded1p), a member of the DEAD-box family, has recently been shown to be essential for translation initiation in Saccharomyces cerevisiae. Here, we show that Ded1p purified from Escherichia coli has an ATPase activity, which is stimulated by various RNA substrates. Using an ...
Tuteja N, Vashisht AA, Tuteja R (2008) Translation initiation factor 4A: a prototype member of dead-box protein family. Physiol Mol Biol Plants 14: 101-107Tuteja N, Vashisth AA, Tuteja R (2008) Translation initiation factor 4A: a prototype member of dead-box protein family . Physiol Mol ...
RNA helicases of the DEAD-box family are required for different cellular processes such as transcription, pre-mRNA processing, ribosome biogenesis, nuclear mRNA export, translation initiation, RNA turnover and organelle function. The structure of the core element, which contains all the conserved moti...