A defucosylated anti-CD317 antibody exhibited enhanced antibody-dependent cellular cytotoxicity against primary myeloma cells in the presence of effectors from patients. Cancer Sci. 2010; 101 (10):2227–2233.T. Ishiguro, S. Kawai, K. Habu et al., "A defucosylated anti- CD317 antibody ...
In this model, the chimeric anti-CCR4 monoclonal antibody (mAb), KM2760, the Fc region of which is defucosylated to highly enhance ADCC, showed potent antitumor activity by human ADCC against CCR4 expressing tumor cell lines. In addition, KM2760 significantly increased the number of tumor-...
Furthermore, the potent ADCC mediated by defucosylated anti-CCR4 mAb, observed here in vivo in humanized mice, will be exploited in clinical trials in the near future. 展开 关键词: leukemia/lymphoma IL-2Rgamma(null) incompatibility cells immunotherapy ...
This phase 1/2 study evaluated the efficacy of mogamulizumab, a defucosylated, humanized, anti-CC chemokine receptor 4 monoclonal antibody, in 41 pretreated patients with cutaneous T-cell lymphoma. No dose-limiting toxicity was observed and the maximum tolerated dose was not reached in phase 1...
FUT8−/− cell lines have morphology and growth kinetics similar to those of the parent, and produce completely defucosylated recombinant antibodies. FUT8−/−-produced chimeric anti-CD20 IgG1 shows the same level of antigen-binding activity and complement-dependent cytotoxicity (CDC) as the...
Besuchen Sie ChemicalBook finden Sie mehr FUCOSYLATED-BSA-COLLOIDAL GOLD Informationen wie chemische Eigenschaften, Struktur, Schmelzpunkt, Siedepunkt, Dichte, Summenformel, Molekulargewicht, physikalische Eigenschaften, Toxizität Informationen Zollco
Besuchen Sie ChemicalBook finden Sie mehr Monogalactosylated fucosylated asialo, agalacto, biantennary (G-NGA2F) Informationen wie chemische Eigenschaften, Struktur, Schmelzpunkt, Siedepunkt, Dichte, Summenformel, Molekulargewicht, physikalische Eigensch
Depolymerized holothurian glycosaminoglycan (DHG) is a fucosylated chrondroitin sulfate that possesses antithrombin-independent antithrombotic properties a... JP Sheehan,EN Walke - 《Blood》 被引量: 94发表: 2006年 DEPOLYMERIZED FUCOSYLATED GLYCOSAMINOGLYCAN AND PREPARATION METHOD THEREOF Disclosed is a met...
CD16 pre-ligation by defucosylated tumor-targeting mAb sensitizes human NK cells to γc cytokine stimulation via PI3K/mTOR axisObinutuzumabCD16Natural killer cellsIFN-γPI3K/mTORmiR-155Obinutuzumab is a glycoengineered tumor-targeting anti-CD20 mAb with a modified crystallizable fragment (Fc) domain...
The addition of the GlcNAc residue on O-fucosylated EGF 12 induces a significant conformational change in the adjacent tripeptide sequence, Gln(462)Asn(463)Asp(464), which is a motif involved in the natural, enzymatic O-fucosylation at the conserved site (Cys(461)X(4)Ser/ThrCys(467)). ...