Upon recruitment by Fc-ARM-P, defucosylated antibodies efficiently activated natural killer cells and induced ADCC, whereas antibodies with intact N-glycans did not. The results suggest that the affinity between recruited antibodies and CD16a, a type of Fc receptor expressed on immune cells, could...
Nascent proteinsClick-IT AHA (L-Azidohomoalanine)Azide5 mgC10102 Click-iT HPG (L-homopropargylglycine)Alkyne5 mgC10186 OPP (O-propargyl-puromycin)Alkyne5 mgC10459 Geranylgeranylated proteinsClick-iT geranylgeranyl alcoholAzide5 mgC10249 Fucosylated glycan...
Given the strong growth phenotype that we observed in both lifecycle stages, additional roles for GDP-fucose and fucosylated glycans in this organism cannot be ruled out. Further studies to identify fucosylated glycoproteins in T. brucei will be needed to learn more about the role of this sugar ...
Nevertheless, it has to be considered that human erythrocytes contain significant levels of fucosylated proteins and their putative degradation may release monosaccharides that might be activated by the parasite. Furthermore, red blood cells also have a significant pool of GDP-Fuc (data not shown) ...
(A) Decrease in complex-fucosylated glycans; (B) Decrease in high-mannose and hybrid glycans; (C) Decrease in sialylated glycans; (D) Disappearance of sialylated glycans; (E) Accumulation of high-mannose and complex glycans; (F) New complex-fucosylated and sialylated glycans. Error bars ...
Tamm-Horsfall protein contains exclusively N-linked glycans, mainly of polyantennary type largely sialylated and fucosylated, but also high-mannose glycans. Only a portion of the Tamm-Horsfall protein is released as soluble protein by the action of proteases and in a minor amount by a cell-...
6. Ščupáková K, Adelaja OT, Balluff B, et al. Clinical importance of high-mannose, fucosylated, and complex N-glycans in breast cancer metastasis[J]. JCI Insight, 2021, 6(24): e146945. DOI:10.1172/jci.i...
22.Nie H, Liu X, Zhang Y, et al. Specific N-glycans of hepatocellular carcinoma cell surface and the abnormal increase of core-alpha-1, 6-fucosylated triantennary glycan via N-acetylglucosaminyltransferases-IVa regulation [J]....
Herpesvirus-induced expression of sLe(x) and related O-linked glycans in the infected cell 来自 ResearchGate 喜欢 0 阅读量: 59 作者: K Nyström 摘要: Lewis antigens constitute a family of fucosylated carbohydrate antigens (glycotopes), involved in leukocyte homing and related immunological ...
Upon recruitment by the molecules, defucosylated antibodies showed superior cytotoxicity by ADCC than antibodies with intact N‐glycans. This report provides insight into the development of immunotherapy. doi:10.1002/cbic.202000577Koichi SasakiMinori HaradaTakuma YoshikawaHiroshi TagawaYui Hara...