In more complicated modeling cases, such as modeling a protein structure in contact with a ligand, sequence information itself may not be enough and more biological information is required for a successful modeling process. SCOP and PFAM are two databases providing protein domain information which ...
the understanding of chemical structure in the early 1800s, the elucidation of atomic structure in the early 1900s, the comprehension of polymer structure in the 1920s, the fust three-dimensional structure of protein in 1957 and more recerrtly, the determination of gene structure in the 1970s...
Structure-based identification of binding sites, native ligands and potential inhibitors for G-protein coupled receptors. G-protein coupled receptors (GPCRs) are the largest family of cell-surface receptors involved in signal transmission. Drugs associated with GPCRs represent... CN Cavasotto,AJW Orr...
Currently, PTGL comprises topologies of 54 859 protein structures. Main structural patterns for common structural motifs like TIM-barrel or Jelly Roll are pre-implemented, and can easily be searched. 展开 关键词: Animals Humans Proteins Crystallography, X-Ray Protein Conformation Protein Structure, ...
For instance, formation of G-quadruplex structure by the expanded repeat r(GGGGCC)nin intron 1 of c9orf72 gene sequesters TDP-43 that leads to impairment of its function and causes ALS disorder31,32. However, certain G-quadruplex and protein interactions are also beneficial for cells, such as...
protein structuresequence alignmentintegrated systemsResearchers have been wishing for years for a database integrating protein sequences and protein structures. A group from the United Kingdom has achieved this long-sought objective.doi:10.1038/335745a0None...
Use Standalone RPS-BLAST and rpsbproc(https://ftp.ncbi.nih.gov/pub/mmdb/cdd/rpsbproc/e) (这个网址好像失效了)to compute and retrieve(检索) domain annotation programmatically. Basic Protocol3demonstrates how to identify protein domains for a batch of protein queries of greater than 4000.演示了...
What if I can’t find the protein I’m interested in? If you can’t find the structure you’re looking for, here are some suggestions to improve your search results: Try searching by protein or gene name rather than specific UniProt accession. ...
TOPOFIT-DB (T-DB) is a public web-based database of protein structural alignments based on the TOPOFIT method, providing a comprehensive resource for comparative analysis of protein structure families. The TOPOFIT method is based on the discovery of a saturation point on the alignment curve (...
AMASS: a database for investigating protein structures. Modern techniques have produced many sequence annotation databases and protein structure portals, but these Web resources are rarely integrated in ways tha... Clinton,J,Mielke,... - 《Bioinformatics》 被引量: 0发表: 2014年 List of genome an...