步骤1、我们可以在GWAS Catalog中按论文的PMID(33414549)进行搜索: 步骤2、下拉至Studies,点击非认知能力表型相应的编号:GCST90011874: 步骤3、找到Full Summary Statistics,这里代表的就是能够获得完整GWAS Summary Results的地方(again,凡事没有绝对,不一定每一个表型都提供): 步骤4、下载GWAS Summary Results至本地...
representing and modeling data in the NHGRI GWAS catalogVJ Carey
GWAS Catalogview FAIRsharing entry Metabolomics & Proteomics We ask authors to submit proteomics data to members of theProteomeXchangeconsortium (listed below), following theMIAPE recommendations. MassIVEview FAIRsharing entry MetaboLightsview FAIRsharing entry ...
GWAS Catalog (European Bioinformatics Institute, 2023); https://www.ebi.ac.uk/gwas/ Yang, J. et al. GCTA: a tool for genome-wide complex trait analysis. Am. J. Hum. Genet. 88, 76–82 (2011). Article CAS PubMed PubMed Central Google Scholar Gupta, A. immunogenomics/sc-h2: v3.0...
write.table(f,"GWAS_AF_Finn.txt",sep = "\t",row.names = FALSE,quote = FALSE) #SMR/GSMR格式转化---GWAS catalog格式 library(tidyverse) library(data.table) setwd("稳健分析GCST274790_AF6414andFinn/GSMR/") g<-fread("AF-GCST006414-build37.f.tsv.gz") #读取GWAS数据 head(g) f<-sele...
The GWAS summary statistics data of the three common psychiatric disorders were downloaded from the Psychiatric Genomics Consortium (https://www.med.unc.edu/pgc), and the GWAS summary statistics data of the two non-psychiatric disorders were accessed from the GWAS Catalog under accession IDs GCST...
分析方法: 使用MANOVA对寿命、健康寿命、父母寿命三个不同的GWAS summary文件进行荟萃分析。随后对感兴趣的基因座按照性别和年龄进行分层分析,用GWAS catalog和PhenoScanner查找感兴趣基因的相关表型。使用SMR进行基因表达共定位分析,使用FUMA的Gene2Func进行基因富集分析,使用TwoSampleMR进行孟德尔随机化随机化; ...
The Database of Genotypes and Phenotypes (dbGaP), hosted by NLM, has been designated as the data repository for all GWAS supported by the U.S. government via its National Institutes of Health (NIH). This database, which contains both prospectively obtained and previously existing data, is one...
Methods: MR-Base and LD Hub are built on a database of harmonized summary genetic data from GWAS consortia, dbGAP and the GWAS catalog, roughly corresponding to >1,200,000 individuals and approximately 2000 phenotypes. Queries to both are submitted through platform-specific web portals. LD Hub...
Even if it is hard to control for genotypic, phenotypic, and environmental variance, however, at least one has some idea of what these concepts mean in GWAS research.With the HMP it is different. Distinctions between genotype and phenotype or between genomic and environmental factors are ...