Pharmaceutical sciences Potency and pharmacokinetic enhancement of D-peptide HIV-1 entry inhibitors THE UNIVERSITY OF UTAH Michael S. Kay RedmanJoseph StapleyPeptides are a powerful class of therapeutics with high potency, high specificity,low immunogenicity, and effective methods of discovery. However,...
computational protein designd‐helical peptide designpeptidesprotein–protein interactionsTNFα binding peptideCompared to small molecule drugs, peptide therapeutics provides greater efficacy, selectivity, and safety. The intrinsic disadvantages of peptides are their sensitivity to proteases. To overcome this,...
In the latter two cases, D-peptide therapeutics reached the clinical trial phase (ClinicalTrials.gov identifiers: NCT04672083 and NCT04711486). Despite its potential, MIPD suffers from some limitations that impede its broader adoption. The current technical means of chemical D-protein synthesis limit...
Peptides are experiencing a new era in medical research, finding applications ranging from therapeutics to vaccines. In spite of the promising properties of peptide pharmaceuticals, their development continues to be hindered by three weaknesses intrinsic to their structure, namely protease sensitivity, cle...
International Journal of Peptide Research and Therapeutics (2024) De novo design of proteins housing excitonically coupled chlorophyll special pairs Nathan M. Ennist Shunzhi Wang David Baker Nature Chemical Biology (2024) De novo design of immunoglobulin-like domains Tamuka M. Chidyausiku Soraia...
However, the oral delivery of biologics is associated with a range of significant challenges due to the large drug molecular size, the low physical and chemical stability and the inherently low ability of these therapeutics to cross biological barriers, such as the intestinal mucosa [1, 2]. An...
Peptides are short chains of amino acids that can bind to proteins and change their function. They show high binding affinity, low toxicity, and are easy to synthesize, all of which makes peptides ideal for use in drug development, and many naturally occ
International Journal of Peptide Research and Therapeutics The International Journal of Peptide Research and Therapeutics publishes the latest developments in peptide therapeutics and high quality research covering all aspects of peptide science. The journal brings together in a single source th... S Nethe...
Peptide-induced self-assembly of therapeutics into a well-defined nanoshell with tumor-triggered shape and charge switch. Chem. Mater. 30, 7034–7046 (2018). Article ADS CAS PubMed PubMed Central Google Scholar He, W. et al. Turning a Luffa protein into a self-assembled biodegradable ...
2022年12月19日,Entrada Therapeutics(NASDAQ:TRDA) 宣布其旗下进展最快的Peptide-ASO产品ENTR-601-44的IND申请被FDA叫停。而就在2022年12月8日Entrada临床前资产ENTR-701与Vertex达成超7亿美元的合作。 叫停的原因还有待更进一步数据公布,分析...