There have been rapid developments in the field of peptide therapeutics since the advent of insulin therapy in the 1920s. Conventionally, like other drugs, peptides/proteins were also delivered intravenously, but due to low patient compliance, other modes of delivery like oral and nasal were ...
Oral administration of drugs is a two-edged sword – on one hand it is a non-invasive and easy-to-handle administration of drugs, on the other hand macromolecular pharmaceutical compounds cannot easily cross the epithelial barrier to reach systemic circulation or they could be inactivated in the...
PTC124-induced suppression of PTC was also tested in clinical trials with DMD patients. In the phase IIA trial, an increased expression of the full-length dystrophin was shown in patients’ biopsies after 28 days of oral administration of PTC124; one third of the patients demonstrated an increa...
- 《Clinical Pharmacology & Therapeutics》 被引量: 164发表: 1992年 Pharmacokinetics and Pharmacodynamic Effects of Oral GLP‐1 and PYY3‐36: A Proof‐of‐concept Study in Healthy Subjects Clinical Pharmacology & TherapeuticsBeglinger C, Poller B, Arbit E, et al. Pharmacokinetics and pharmacodynamic...
oral deliveryoral peptide prodrugspermeation enhancer toxicologysonophoresisThis special issue of Tissue Barriers contains a series of reviews with the common theme of how biological barriers established at epithelial tissues limit the uptake of macromolecular therapeutics. By improving our functional ...
Pancreatic ductal adenocarcinoma (PDAC) is an aggressive cancer that is most frequently detected at advanced stages, limiting treatment options to systemic chemotherapy with modest clinical responses. Here, we review recent advances in targeted therapy a
Fig. 2. Design and construction of UCNP-based therapeutics. Photochemical reactions, mediated by UV light, play a significant role in chemical biology, advanced imaging, and drug delivery systems. Nevertheless, as mentioned, UV radiation produces an overly large radiation area, severe phototoxicity,...
Importance of rigidity in designing small molecule drugs to tackle protein–protein interactions (PPIs) through stabilization of desired conformers. J. Med. Chem. 61, 4283–4289 (2018). Article CAS PubMed Google Scholar Doak, B. C., Over, B., Giordanetto, F. & Kihlberg, J. Oral ...
Sorafenib is an oral TKI that targets the angiogenesis and proliferation pathways of tumors by blocking vascular endothelial growth factor receptor (VEGFR) 1–3, platelet-derived growth factor receptor (PDGFR) β-pathways, and Raf-MEK-ERK signaling, all of which participate in the pathogenesis of ...
(3D) cell technology and future stem cell applications. Specifically, we highlight the following crucial domains: 1) sources of pluripotent cells; 2) next-generationin vivodirect reprogramming technology;3) cell types derived from PSCs and the influence of genetic memory; 4) induction of ...