Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. In this Perspective, we summarize key trends in peptide drug disco...
Since the introduction of insulin almost a century ago, more than 80 peptide drugs have reached the market for a wide range of diseases, including diabetes, cancer, osteoporosis, multiple sclerosis, HIV infection and chronic pain. In this Perspective, we summarize key trends in peptide drug ...
今天阅读了《Trends in peptide drug discovery》这篇综述 网页链接 目前多肽药物开发龙头企业 Bicycle 和 PeptiDream 是值得关注的企业,其中 PeptiDream 仅在 2021 就与外界达成了 50 多亿美元的交易。 文章总结了理想多肽药物的主要特征及理想靶点的特点:
Proteins and peptides have a great potential as therapeutic agents; they have higher efficiency and lower toxicity, compared to chemical drugs. However, th
摘要: New opportunities arise through the development of new materials for the design and fabricationof drug delivery vehicles and carriers; new challenges are posed We also intend to deal with topicssuch as the delivery of endogenous molecules, vaccines and new关键词: Peptides ...
in inter-individual variations in pharmacotherapy; (2) current status and trends in assessing drug–drug interactions, especially interactions between drugs and herbs, between drugs and therapeutic biologics, and microbiota-mediated interactions; (3) advances in understanding the effects of diseases on ...
Nasal route of drug delivery is commonly known for treatment of local ailments like-cold, cough, rhinitis etc. Recently, efforts have been made to deliver various drugs, specially peptides and proteins, through nasal route for systemic use; utilizing the principles and concepts of rate controlled...
drug innovations is expected to fuel the growth of peptide–drug conjugates (PDCs) market in the near future. Also, in the coming days, there will be rapid approval of peptide drug conjugates in treating cancers due to the robust clinical pipeline of drugs. Despite these,...
Methodological errors in Medical Research: by B. Andersen, Blackwell Scientific Publications, 1990. £35.00 (viii + 270 pages) ISBN 0 632 02137 3 Ryan J. Huxtable Page 77 select article Principles of drug action, the basis of pharmacology (3rd edn): edited by William B. Pratt and Palmer...
The 224 (56%) non-olfactory GPCRs that are yet to be explored in clinical trials have broad untapped therapeutic potential, particularly in genetic and immune system disorders. Further trends in GPCR drug discovery can be analysed in an interactive resource in the GPCRdb database. ...