Glucuronyl C5 epimerase is a key enzyme in the biosynthesis of heparin and heparan sulfate (HS), which are complex sulfated glycosaminoglycans ( GAGs ) composed of alternating hexuronic acid and glucosamine residues. Both species are synthesized as proteoglycans but on different core proteins ( Esko...
Kiev, Ukraine; 4Engelhard Institute of Molecular Biology RAS, Moscow, Russia BACKGROUND: D-Glucuronyl C5-epimerase (GLCE) is a key enzyme involved in the biosynthesis of heparan sulphate proteoglycans, which has an important role in cell – cell and cell – matrix interactions and signalling. ...
英文名字 Rabbit anti-human D-glucuronyl C5-epimerasel polyclonal Antibody 供应商 MyBioSource 产品货号 MBS1488634 产品报价 ￥询价/0.05mg ￥询价/0.1mg ￥询价/其它规格 产品说明书 点击查看 购买方式 MyBioSource中国区金牌代理,部分产品现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我...
Heterogeneity of D-glucuronyl C5-epimerase expression and epigenetic regulation in prostate cancer. Cancer Medicine 2013; doi:10.1002/cam4.108Prudnikova TY, Soulitzis N, Kutsenko OS, Mostovich LA, Haraldson K, Ern- berg I, et al. Heterogeneity of d-glucuronyl C5-epimerase expression and ...
The TCF4/尾-catenin pathway and chromatin structure cooperate to regulate D-glucuronyl C5-epimerase expression in breast cancer. Epigenetics 2012 ; 7:930 - 9; http://dx.doi.org/ 10.4161/epi.21199 ; PMID: 22805760 [Taylor & Francis Online]...
Decreased expression of human D-glucuronyl C5-epimerase in breast cancer. Int J Cancer 2008; 122:1172-6; PMID:17985344; http://dx.doi.org/10.1002/ijc.23203.Grigorieva E, Eshchenko T, Rykova VI, Chernakov A, Zabarovsky ER, Sidorov SV: Decreased expression of human D-glycuronyl C5-...
O-13 D-glucuronyl C5-epimerase inhibits breast cancer cells proliferation through the tumour suppressor genes activationPrudnikovaT. Y.DomanitskayaN. V.MostovichL. A.PavlovaT. V.KashubaV. I.EUROPEAN JOURNAL OF CANCER -SUPPLEMENT-
miRNA-218 contributes to the regulation of D-glucuronyl C5-epimerase expression in normal and tumor breast tissues. Tatiana Y. Prudnikova,Luydmila A. Mostovich,Vladimir I. Kashuba. EPIGENETICS . 2012Prudnikova TY, Mostovich LA, Kashuba VI, Ernberg I, Zabarovsky ER, Grigorieva EV. miRNA-...
266 MiRNA-218 Regulation of Human D-glucuronyl C5-epimerase Expression in Breast and Prostate CancerELISAIgMLaboratoriesUnited StatesWest Nile virusInfections of avian pathogenic Escherichia coli (APEC) result in annual multimillion-dollar losses to the poultry industry. Despite this, little is known ...
D-glucuronyl C5-epimerase (Glce) is a crucial enzyme in HS synthesis, converting D-glucuronic acid (GlcA) to L-iduronic acid (IdoA) to increase HS flexibility. This modification of HS is important for protein ligand recognition. We have determined the crystal structures of Glce in apo ...