供货周期 两周货号 C5-epimerase 重组人D-葡萄糖醛酸C5差向异构酶惠诚生物 化学品名: 重组人D-葡萄糖醛酸C5差向异构酶 分子量:69 kDa 规格1: 0.05IU 规格2: 0.1IU 纯度:>95% 别名: GLCE,HSEPI,glucuronic acid epimerase 酸乙酰肝素(HS)作为一种广泛分布于细胞表面和胞外基质的复杂结构的糖...
The glucuronyl C5 epimerase (HSepi) is one of the modification enzymes involved in biosynthesis of heparan sulfate (HS) and heparin, catalyzing the epimerization of d-glucuronic acid (GlcA) to l-iduronic acid (IdoA) at polymer level. IdoA is critical for HS and heparin to interact with ...
由于最重要的抗凝药物肝素同HS享有相同的生物合成酶具有相同的生物合成途径。由于IdoA对于肝素发挥其抗凝血活性具有非常重要的作用,D-葡萄糖醛酸C5差向异构酶对于用酶组合法制备生物工程化的肝素就显得尤其重要,上海惠诚生物优势供应重组人D-葡萄糖醛酸C5差向异构酶 Recombinant Human D-glucuronyl C5-epimerase,咨询订...
Analysis of Drosophila Glucuronyl C5-Epimerase 喜欢 0 阅读量: 20 摘要: During the biosynthesis of heparan sulfate (HS), glucuronyl C5-epimerase (Hsepi) catalyzes C5-epimerization of glucuronic acid (GlcA), converting it to iduronic acid (IdoA). Because HS 2- O -sulfotransferase (Hs2st) ...
Kiev, Ukraine; 4Engelhard Institute of Molecular Biology RAS, Moscow, Russia BACKGROUND: D-Glucuronyl C5-epimerase (GLCE) is a key enzyme involved in the biosynthesis of heparan sulphate proteoglycans, which has an important role in cell – cell and cell – matrix interactions and signalling. ...
英文名字 Rabbit anti-human D-glucuronyl C5-epimerasel polyclonal Antibody 供应商 MyBioSource 产品货号 MBS1488634 产品报价 ￥询价/0.05mg ￥询价/0.1mg ￥询价/其它规格 产品说明书 点击查看 购买方式 MyBioSource中国区金牌代理,部分产品现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我...
D-glucuronyl-C5-epimerase (Glce) is a key HS chain modifying enzyme that catalyses the conversion of glucuronic acid into iduronic acid, a biosynthetic step that enhances HS biological activity. In this study the role of Glce during early zebrafish development has been investigated./p pResults...
Targeted Disruption of Hsepi Results in Neonatal Lethality with Respiratory Failure—The GlcA C5-epimerase is encoded by a single Hsepi gene with three exons and accounts for the formation of IdoA units in HS biosynthesis (12, 13). To assess the functional significance of IdoA residues in HS...
Two Glce-like proteins (Glce-A and -B) are expressed in zebrafish at all times. They are the products of two distinct genes that, based on chromosomal mapping, are both orthologues of the same single human gene. Transcripts for both proteins were detecte
Glucuronyl C5-epimerase (Hsepi) catalyzes the conversion of glucuronic acid to iduronic acid in the process of heparan sulfate biosynthesis. Targeted interruption of the gene, Glce, in mice resulted in neonatal lethality with varied defects in organ development. To understand the molecular mechanisms...