The glucuronyl C5 epimerase (HSepi) is one of the modification enzymes involved in biosynthesis of heparan sulfate (HS) and heparin, catalyzing the epimerization of d-glucuronic acid (GlcA) to l-iduronic acid (IdoA) at polymer level. IdoA is critical for HS and heparin to interact with ...
由于IdoA对于肝素发挥其抗凝血活性具有非常重要的作用,D-葡萄糖醛酸C5差向异构酶对于用酶组合法制备生物工程化的肝素就显得尤其重要,上海惠诚生物优势供应重组人D-葡萄糖醛酸C5差向异构酶 Recombinant Human D-glucuronyl C5-epimerase,咨询订购热线021-60498804 Cat. Number: HA11765 Product Name: Recombinant Human...
Kiev, Ukraine; 4Engelhard Institute of Molecular Biology RAS, Moscow, Russia BACKGROUND: D-Glucuronyl C5-epimerase (GLCE) is a key enzyme involved in the biosynthesis of heparan sulphate proteoglycans, which has an important role in cell – cell and cell – matrix interactions and signalling. ...
During the biosynthesis of heparan sulfate (HS), glucuronyl C5-epimerase (Hsepi) catalyzes C5-epimerization of glucuronic acid (GlcA), converting it to iduronic acid (IdoA). Because HS 2- O -sulfotransferase (Hs2st) shows a strong substrate preference for IdoA over GlcA, C5-epimerization ...
D-glucuronyl-C5-epimerase (Glce) is a key HS chain modifying enzyme that catalyses the conversion of glucuronic acid into iduronic acid, a biosynthetic step that enhances HS biological activity. In this study the role of Glce during early zebrafish development has been investigated./p pResults...
英文名字 Rabbit anti-human D-glucuronyl C5-epimerasel polyclonal Antibody 供应商 MyBioSource 产品货号 MBS1488634 产品报价 ￥询价/0.05mg ￥询价/0.1mg ￥询价/其它规格 产品说明书 点击查看 购买方式 MyBioSource中国区金牌代理,部分产品现货库存。银行转账、电汇、支票、现金,在线支付宝及网银支付,或直接与我...
Two Glce-like proteins (Glce-A and -B) are expressed in zebrafish at all times. They are the products of two distinct genes that, based on chromosomal mapping, are both orthologues of the same single human gene. Transcripts for both proteins were detecte
We report that targeted disruption of the murine d-glucuronyl C5-epimerase gene results in a structurally altered HS lacking IdoA. The corresponding phenotype is lethal, with renal agenesis, lung defects, and skeletal malformations. Unexpectedly, major organ systems, including the brain, liver, ...
Glucuronyl C5 epimerase is a key enzyme in the biosynthesis of heparin and heparan sulfate (HS), which are complex sulfated glycosaminoglycans ( GAGs ) composed of alternating hexuronic acid and glucosamine residues. Both species are synthesized as proteoglycans but on different core proteins ( Esko...
Purified mouse C5- new epimerase, fragments thereof, nucleic acid encoding it, and the invention is directed to the recombinantly produced. The present invention is also directed to the N-terminal fragment are useful fragment in the fusion protein constructs to enhance the activity of the ...