Thecytotoxicityofacetaminophenhas been demonstrated in cultures of HeLa cells, L929 and 3T3 murine fibroblasts, chick embryo neurons, rat embryonic and skeletal muscle, peripheral blood lymphocytes, and lung and dermal cells. In addition, cytotoxicity of acetaminophen has been evaluated in the BF-2 fi...
This effect was independent of any osmotic effect, when sucrose was run as a control. We conclude that primary cultures of midbrain neurons are sensitive to relatively low concentrations of ethanol, compared to cell culture preparations used by other investigators. 展开 ...
In addition, a previous study indicated that the functional TRPM2 expression level in pyramidal neurons changes during different development stages in mice15, suggesting that the number of TRPM2 channels expressed on the cell surface is important. Here, in order to clarify the role of the TRPM2...
Apoptosis, programmed cell death, via numerous triggers including death receptor ligand bindi... M Watabe,K Hishikawa,A Takayanagi,... - 《Journal of Biological Chemistry》 被引量: 342发表: 2004年 Leptin excites proopiomelanocortin neurons via activation of TRPC channels. Leptin can exert its ...
Amyotrophic lateral sclerosis (ALS) is a disease in which the motor neurons die in a progressive manner, leading to paralysis and muscle wasting. ALS is al... Zetterström, Per - 《Department of Pharmacology\\&\\clinical Neuroscience》 被引量: 49发表: 2011年 Cerebrospinal fluid from amyotrop...
In prion disease, accumulation of PrP Sc and PrP amyloid in the central nervous system (CNS) is accompanied by activation of microglial cells, hypertrophy and proliferation of astrocytes, and degeneration of neurons, leading to variable degrees of atrophy of the target regions. The temporal and an...
when it was added to the culture with CdCl 2 simultaneously.It can also inhibit Cd 2+ ion from entering the cells.Conclusions Cd 2+ ion can inhibit the proliferation of V79 cell,while Zn 2+ can antagonize in certain extent.Zn 2+ ion may impair the toxicity of Cd 2+ by interference ...
Vertically aligned and densely packed ZnO nanowire arrays are synthesized using a solution-based method and used as a substrate for cell culture. The metabolism levels of all three types of cells cultured on ZnO nanowire arrays are studied using the 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-...
A common feature of ALS is formation of inclusion bodies (IBs) containing protein aggregates in the cytoplasm and nucleus of motor neurons3,4. These IBs often contain proteins encoded by ALS-causative genes carrying a mutation. More than 20 proteins have been identified in the ALS-associated ...
Co-culture experiments were performed using NK cells and FACS-sorted dentate gyrus cell types including neurons (CD15-CD29lowCD24hi), microglia (CD11b+CD45int), astrocytes (GLAST+), neural stem cells (GLAST+EGFR+ CD24−) and neuroblasts (GLAST−EGFR−CD24low). NK cell proliferation ...