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Up-regulation of Ngb was also observed in cultured neuronal cell lines (PC12 and HN33) after exposure to hypoxia (0.3% O2 for PC12, 0.3% and 1% O2 for HN33) for 24 h (11). Studies have also proved the induction of Ngb by ischemia/hypoxia in vivo, but the situation more complex....
Neuronal Nicotinic Acetylcholine Receptors - Targets for the Development of Drugs to Treat Cognitive Impairment Associated with Schizophrenia and Alzheimer... for the Development of Drugs to Treat Cognitive Impairment Associated with Schizophrenia and Alzheimer's Disease, " Current Topics in Medicinal Chemis...
Nerve cell typing In the nervous system, there is a difference among individual neurons because there are some unique copy number variations in nerve cells [37]. The heterogeneity among these neurons makes it difficult to study how brain circuits are formed and to resolve neuronal reconnections. ...
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In this review, we discuss recent findings on the toxiceffects of amyloid-boligomers, their physico-chemical prop-erties and the possible pathways of their formationin vitroandin vivo.Keywords:Alzheimer’s disease;b-amyloid; neuronal celldeath.IntroductionAlzheimer’s disease (AD) is one of the ...
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[138]. HSV can also be used to deliver a therapeutic gene of interest, especially to the nervous system. The advantages in using HSV include its wide host range, its ability to accommodate large genes, and its ability to establish long-lived asymptomatic infections in neuronal cells. However,...
Such inhibitors would interfere with the ability of the toxin to bind to its neuronal receptor. LC inhibitors would be crucial to rescuing nerve activity after toxin internalization. In the search for such therapeutics, a number of short 'hinge' peptide inhibitors of the BoNT/A LC have been ...