Cytotoxic T cells are CD8-postive T cells that are specialized for the direct killing of cells that are infected (particularly with viruses), cancerous or damaged in other ways. They express the glycoprotein CD8, as well as T cell receptors that recognize antigenic peptides presented by MHC cl...
CD8+ T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: a clinicopathological analysis. J Pathol 2001;193:383. [PubMed: 11241420]AhmedAF,OhtaniH,NioM et al.CD8+ T cells infiltrating into bile ducts in biliary atresia do not appear to ...
Cytotoxic T cells (CTLs) are differentiated effector T lymphocytes that specifically kill target cells bearing an appropriate antigenic complex (peptide–MHC) recognized by their T cell receptor. From: Encyclopedia of Immunology (Second Edition), 1998 ...
Cytotoxic T cells generated against heteroclitic peptides kill primary tumor cells independent of the binding affinity of the native tumor antigen peptide Cytotoxic T cells generated against heteroclitic peptides kill primary tumor cells independent of the binding affinity of the native tumor antigen ...
Cytotoxic T‐lymphocyte‐associated protein 4 (CTLA‐4) is one of the important molecules that regulate the anti‐melanoma T‐cell response. Currently, there are some reports showing that CTLA‐4 is expressed not only by T cells but also by various kinds of tumor cells, including melanoma cell...
Mechanistically, we provide evidence that CD8+ T cells drive axon degeneration in a T-cell receptor- and granzyme B-dependent manner. Cytotoxic neural damage is further aggravated by systemic inflammation in aged but not adult mice. We also find increased densities of T cells in white matter ...
Durable control in LTNP/EC is likely mediated by highly functional virus-specific CD8+ T-cells. Protective Human Leukocyte Antigen (HLA) class I alleles, like B*27 and B*57, are present in most, but not all LTNP/EC, providing an opportunity to investigate features shared by their HIV-...
Tumors Suppress In Situ Proliferation of Cytotoxic T Cells by Promoting Differentiation of Gr-1+ Conventional Dendritic Cells through IL-6. et al.Tumors suppress in situ proliferation of cytotoxic T cells by promoting differentiation of Gr-1 (+) conventional dendritic cells through IL-6[J]... ...
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Autophagy within the antigen donor cell facilitates efficient antigen cross-priming of virus-specific CD8+ T cells Cross-presentation of cell-associated antigen is important in the priming of CD8(+) T-cell responses to proteins that are not expressed by antigen-presenti... M Uhl,O Kepp,H Jus...