Cytotoxic T lymphocytes (CTL) are major effectors in cell-mediated immune reactions. Once activated they search out and bind to cells that express inappropriate of "foreign" structures on their surfaces and, by a mechanism that remains unclear, program them to die. The CTL then move away to ...
Lethal hit delivery by cytotoxic T lymphocytes (CTL) towards B lymphoma cells occurs as a binary, “yes/no” process. In non-hematologic solid tumors, however, CTL often fail to kill target cells during 1:1 conjugation. Here we describe a mechanism of “
Lytic cell death triggers an antitumour immune response. However, cancer cells evade lytic cell death by several mechanisms. Moreover, a prolonged and uncontrolled immune response conversely leads to T-cell exhaustion. Therefore, an oncolytic system capa
Cytotoxic lymphocytes, comprising cytotoxic T lymphocytes (CTLs; e.g., CD8+) and NK cells, destroy their target cells via the secretion of perforin and granzyme molecules across the immunological synapse [1]. From: Trends in Immunology, 2022 About this pageAdd to MendeleySet alert Also in sub...
Furthermore, we demonstrate that neutralization of TGF-β restores expression of these genes in tumor-specific CD8+ T cells in vivo, leading to tumor clearance. These results suggest that TGF-β suppresses CD8+ T cell cytotoxicity in vivo through repression of a distinct program of cytotoxic ...
Systems biologyAssociated content Metabolic profiling of CD8+ T cells at the single-cell level Madhura Mukhopadhyay Nature Methods Research Highlight 29 Oct 2020 Sections Figures References Abstract Data availability Code availability References Acknowledgements Author information Ethics declarations Additional...
IL-2 is toxic to the patient. The activated T cells are not very cytotoxic and the number of LAK cells that can be produced in vitro and injected in vivo is by necessity limited to a few billion. Few tumors seem to respond to this type of therapy. Thus, while LAK therapy is an imp...
来源期刊 Human Gene Therapy 研究点推荐 Lentivirus-Mediated Gene Transfer T-cell biology acquired immune deficiency syndrome stable gene transfer Primary Unstimulated T Cells Human Tumor Antigen-Specific Cytotoxic T Cells 引用走势 2007 被引量:16 站内活动 0...
Our approach reveals aberrant NK and CD8+T cell biology in MIS-C patients. These cytotoxic cells can regulate one another in response to viral infection6, and the depletion of NK cells has been shown to disrupt CD8+T cell exhaustion, a process where virus-specific CD8+T cells have poor cy...
Mechanical force contributes to perforin pore formation at immune synapses, thus facilitating the cytotoxic T lymphocytes (CTL)-mediated killing of tumor cells in a unidirectional fashion. How such mechanical cues affect CTL evasion of perforin-mediated