Little to no cytotoxicity was observed in RAW264.7 murine macrophages, Jurkat T lymphocytes,RAJI B lymphocytes, and WHTBF-6 lung fibroblasts after 24 hour treatment with up to 2.5 µg/cm2 nanoparticles. Theability for RAW264.7 cells to internalize fluorescent latexbeads was not significantly ...
1.2.2.3.2Cytotoxic T-cells Cytotoxic T-cells, also referred to as CD8+T-cells because they express a CD8 glycoprotein on theirsurface, are the mediators of CMC, killing host cells infected with intracellular pathogens and tumor cells, usingMHC class Irestriction as explained inSection 1.2.2.1....
Lytic cell death triggers an antitumour immune response. However, cancer cells evade lytic cell death by several mechanisms. Moreover, a prolonged and uncontrolled immune response conversely leads to T-cell exhaustion. Therefore, an oncolytic system capa
produce IL-2, IL-12, and IFNγ, which promote the cytotoxic ability of CD8+T cells, leading to targeting of tumor cells for killing. Elevated levels of cytotoxic CD8+T cells in the tumor microenvironment are correlated with improved anti-tumor effects and progno...
Mechanical force contributes to perforin pore formation at immune synapses, thus facilitating the cytotoxic T lymphocytes (CTL)-mediated killing of tumor cells in a unidirectional fashion. How such mechanical cues affect CTL evasion of perforin-mediated
Such high efficacy of CTL-mediated serial killing, however, is rarely observed in patients receiving adoptive transfer of tumor-specific T cell receptor (TCR)-engineered or chimeric antigen receptor (CAR) T cells8. Evidence for effective serial target cell killing after 1 : 1 pairings has ...
Video S2. CTL-mediated killing of a B16F10-MRTFA cell, Related to Figure 2 Video S3. CTL-mediated killing of a B16F10-MRTFB cell, related to Figure 2 Document S1. Figures S1–S7 Table S1. The TCGA melanoma dataset analyzed for Figure 3H and Figures S4A and S4D, related to Figure...
In vitro killing assays showed that T3-HDVax-induced Tr1 cells but not non-Tr1 CD4+ T cells killed mItgb1-pulsed cDC1s but not cDC2s in a GZMB-dependent manner (Fig. 5b and Extended Data Fig. 9e,f). Of note, Tr1 cells harvested from T3-HDVax-treated mice in the presence of ...
The specific killing activity of the induced CTLs against T2pMAGE-A1 278–286 and U251 was much more obvious than in any other control group ( P <0.05). The cytotoxic activity against the T2pMAGE-A1 278–286 and U251 was significantly eliminated by anti-HLA class I mAb W6/32. These...
The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of