Little to no cytotoxicity was observed in RAW264.7 murine macrophages, Jurkat T lymphocytes,RAJI B lymphocytes, and WHTBF-6 lung fibroblasts after 24 hour treatment with up to 2.5 µg/cm2 nanoparticles. Theability for RAW264.7 cells to internalize fluorescent latexbeads was not significantly ...
1.2.2.3.2Cytotoxic T-cells Cytotoxic T-cells, also referred to as CD8+T-cells because they express a CD8 glycoprotein on theirsurface, are the mediators of CMC, killing host cells infected with intracellular pathogens and tumor cells, usingMHC class Irestriction as explained inSection 1.2.2.1....
produce IL-2, IL-12, and IFNγ, which promote the cytotoxic ability of CD8+T cells, leading to targeting of tumor cells for killing. Elevated levels of cytotoxic CD8+T cells in the tumor microenvironment are correlated with improved anti-tumor effects and progn...
Lytic cell death triggers an antitumour immune response. However, cancer cells evade lytic cell death by several mechanisms. Moreover, a prolonged and uncontrolled immune response conversely leads to T-cell exhaustion. Therefore, an oncolytic system capa
The functions of, and interactions between, the innate and adaptive immune systems are vital for anticancer immunity. Cytotoxic T cells expressing cell-surface CD8 are the most powerful effectors in the anticancer immune response and form the backbone of
The phenotype(s) of CTL or possible LAK cell was not then examined. Such promiscuous killing was also observed by stimulating lymphocytes with virus for 7 days (Scholl et al., 1989). The presence of virus specific, but non-MHC-restricted, cytotoxic T cells has been reported for other ...
Tumor cells detach following killing and electrical impedance is reduced which can be measured by the xCelligence system. The ability to adapt the impedance-based approach to assess cell-mediated killing rests on the observation that T cells do not adhere tightly to most surfaces and do not ...
C Condon,SC Watkins,CM Celluzzi,... - PubMed 被引量: 1273发表: 1996年 A peptide encoded by human gene MAGE-3 and presented by HLA-A2 induces cytolytic T lymphocytes that recognize tumor cells expressing MAGE-3 The human MAGE-3 gene is expressed in many tumors of several histological typ...
Mechanical force contributes to perforin pore formation at immune synapses, thus facilitating the cytotoxic T lymphocytes (CTL)-mediated killing of tumor cells in a unidirectional fashion. How such mechanical cues affect CTL evasion of perforin-mediated
Because agents capable of killing tumour cells (cytotoxic drugs) are likely the most promising in the clinic, there is a need for drug sensitivity assays that reliably identify cytotoxic compounds that induce cell death. We recently developed a drug sensitivity assay, called the RNA disruption ...