Cytotoxic T cells are CD8-postive T cells that are specialized for the direct killing of cells that are infected (particularly with viruses), cancerous or damaged in other ways. They express the glycoprotein CD8, as well as T cell receptors that recognize antigenic peptides presented by MHC cl...
The first was to understand how CTL (and, as would be appreciated later, the T-helper cells that promote the functional maturation of CTL) recognize the cells with which they interact, both during the sensitization phase of the CTL reaction, when the decision between self and non-self must ...
THE molecular basis of recognition and target cell killing by cytotoxic T cells is still unknown. Doherty and Zinkernagel showed that mouse cells infected with lymphocytic choriomeningitis virus can be lysed by immune cytotoxic T cells but only if both cell types share at least part of the major...
Deleo et al proposed that ALDH1A1-specific CD8+T cells could recognize cells with CSC-like characteristics, such as ALDH (BREAT) cells in human tumor cell lines, xenograft tumors, and skin lesions, thereby killing tumors; these results support the potential of ALDH1A1-based immunotherapy to ...
One possibility to account for the selective blocking by Lyt-2 and Lyt-3 antisera is that Lyt-2,3 determinants on the surface of cytotoxic T cells have a close spatial relation to the T cell receptor. 展开 关键词: Immunology T lymphocyte Killer cell Differentiation antigens T cell receptor ...
Cytotoxic CD8+ T cells are responsible for the lysis of cells expressing peptides associated with MHC class I molecules and derived from infection with a p... N Chaoul,C Fayolle,C Leclerc - BIO-PROTOCOL 被引量: 0发表: 2016年 in vivo ova-specific cytotoxic cd8 + t cell killing assay Cyt...
Sensitivity of cytotoxic T cells to T-cell mediated cytotoxicity. Nature 252:81–83 - Golstein - 1974 () Citation Context ...lling process. In short-term in vitro cytotoxicity assays, it has been clearly demonstrated that killing by CTL is undirectional; i.e., CTL can only kill target...
CTLs generated against heteroclitic peptides could kill patients' tumor cells, showing that Ig-derived peptides can be presented by the tumor cell and ... S, Harig,M, Witzens,AM Krackhardt,... - 《Blood》 被引量: 146发表: 2001年 Cytotoxic T cells generated against heteroclitic peptide...
non-specificeffectorcell.Perforin/GranzymeBPathwayDirectionalreleaseofgranules(inred).HowdoCTLkilltargetcells?CTLKillingPerforin•ContainedinCTLgranules•Poreformingprotein.•Pokesholesintargetcellmembrane.•HomologoustoC9.Perforinformspolymersthatpokeholesinmembranestoallowenzymesinsidecell.CTLKillingCTLKilling...
CD8+ T-cell–target-cell interactions are characterised by sustained motility of the CD8+ T cell on the target cell. As mentioned above, these mechanical forces can enhance pore formation in the target cell membrane and subsequent target-cell killing via secreted death-inducing granules containing ...