THE molecular basis of recognition and target cell killing by cytotoxic T cells is still unknown. Doherty and Zinkernagel showed that mouse cells infected with lymphocytic choriomeningitis virus can be lysed by immune cytotoxic T cells but only if both cell types share at least part of the major...
Cytotoxic T cells are CD8-postive T cells that are specialized for the direct killing of cells that are infected (particularly with viruses), cancerous or damaged in other ways. They express the glycoprotein CD8, as well as T cell receptors that recognize antigenic peptides presented by MHC cl...
The killing of target cells by cytotoxic T lymphocytes is an efficient way for the immune system to eliminate virusinfected cells, intracellular parasites and tumor cells. T cells and Natural Killer (NK) cells have two major effector mechanisms: (1) the expression of FasL (CD95L), which ...
One possibility to account for the selective blocking by Lyt-2 and Lyt-3 antisera is that Lyt-2,3 determinants on the surface of cytotoxic T cells have a close spatial relation to the T cell receptor. 展开 关键词: Immunology T lymphocyte Killer cell Differentiation antigens T cell receptor ...
Cytotoxic T cells (CTLs) Cytotoxic T cells are an important subset of T cells that respond to intracellular infections such as viruses and malignant cells. These cells have CD8 molecules on their cell surfaces and can regulate the infection by killing infected cells directly. They recognize peptid...
T Lin,W Liu,G Li,F Li,J Yuan 摘要: OBJECTIVE: To investigate the clinicopathologic features of cytotoxic natural killer (NK)/T-cell lymphomas of the lymph nodes. METHODS: Clinicopathologic observations and follow up on 5 cases of cytotoxic NK/T-cell lymphomas of the lymph nodes, ...
CTLs generated against heteroclitic peptides could kill patients' tumor cells, showing that Ig-derived peptides can be presented by the tumor cell and ... S, Harig,M, Witzens,AM Krackhardt,... - 《Blood》 被引量: 146发表: 2001年 Tumor-Specific CD4+ T Lymphocytes from Cancer Patients ...
Specific cytolysis can be described as a two stage process: first, the recognition of target cell antigens by specific receptors at the surface of the `killing' cell; and, second, lysis itself.doi:10.1038/252081a0GOLSTEINPIERRENatureGolstein, P. 1974 . Sensitivity of cytotoxic T cells to ...
CD8+ T-cell–target-cell interactions are characterised by sustained motility of the CD8+ T cell on the target cell. As mentioned above, these mechanical forces can enhance pore formation in the target cell membrane and subsequent target-cell killing via secreted death-inducing granules containing ...
(CTLs) that can recognise mutated cancer cell antigens and thereby enable tumour cell killing. Yet, a significant cohort of cancer patients are non-responsive to ICB treatment and therefore, there is a strong need to discover additional anti-cancer immunomechanisms. Recent work inNatureby Chou ...