Pro-inflammatory cytokines, including interleukin-1, interleukin-6, and tumor necrosis factor, as well as chemotactic cytokines, such as interleukin-8 and other related chemokines, have been detected in inflamed tissues from IBD patients; this has provided even more evidence that these mediators a...
had minimal perivascular inflammation and meningeal inflammation and very few Toxoplasma cysts or organisms in immunoperoxidase-stained preparations of their ... CR Brown,CA Hunter,RG Estes,... - 《Immunology》 被引量: 477发表: 1995年 Chemokines and chemotaxis of leukocytes in infectious meningitis ...
Prolonged inflammation has a profound impact on the cytokine network and the cells they target, consequently altering the outcome of cell populations. The central nervous system is a unique environment that is exquisitely sensitive to cytokines, growth factors, and chemokines; the dysregulation that is...
Cytokines play an important role in the pathogenesis of sepsis and are regulated by a complex network of pro- and anti-inflammatory mediators. Various chemokines sequester neutrophils into the target organ, further augmenting inflammation. Chemokine receptor antagonism represents a major therapeutic ...
Actions of Chemokines and Cytokines Cytokines are involved in virtually every facet of immunity and inflammation, including innate immunity, antigen presentation, bone marrow differentiation, cellular recruitment and activation, and adhesion molecule expression. Which cytokines are produced in response to an...
Chemokines have been shown to be important in both inflammation and carcinogenesis and are able to be measured in saliva with relatively robust methods including enzyme-linked immunosorbent assays (ELISA). Thus it has been hypothesized that patients with oral cancer and oral potentially malignant lesion...
Inflammatory Cytokines in the Pathogenesis of Chronic Heart Failure A large body of evidence, derived through both experimental and clinical studies, supports an important role for inflammatory cytokines and chemokines in the pathogenesis of myocardial dysfunction and adverse cardiac remodeling. Marked elevat...
3. Cytokines and chemokines. J. Allergy Clin. Immunol. 117, S441–S445 (2006). Article CAS PubMed Google Scholar Elenkov, I. J. Neurohormonal-cytokine interactions: Implications for inflammation, common human diseases and well-being. Neurochem. Int. 52, 40–51 (2008). Article CAS Pub...
It causes soft tissue inflammation and bone damage affected by the mediators of both innate and acquired immune system.The inflammatory process is accompanied by large network of cytokines and chemokines. There is high expression of proinflammatory cytokines such as interleukin (IL)-1α, IL-1β, ...
Chemokines and inflammation in osteoarthritis: Insights from patients and animal models Evidence has been building that the pathologic drive for development of osteoarthritis (OA) involves more than simple mechanical "wear and tear." Inflammat... Scanzello,R Carla - 《Journal of Orthopaedic Research》...