Cytokines that function as proinflammatory mediators in one environment may function to suppress inflammation in others. Understanding the molecular mechanisms underlying cytokine expression and cytokine receptor-mediated signal transduction and gene expression is central to the study of immunology and the ...
The innate immune system serves as the first line of defense against invading pathogens; however, dysregulated innate immune responses can induce aberrant inflammation that is detrimental to the host. Therefore, careful innate immune regulation is critical during infections. The coronavirus disease 2019 (...
Whether lower extremity function, as measured according to the Lower Extremity Gain Scale (LEGS), explained the relationship between IL-6, sTNF-αR1, and GDS score was also examined. RESULTS: Participants in the highest categories of IL-6 (≥5.14pg/mL) and sTNF-αR1 (≥2,421pg/mL) ...
Little is known about how hepatitis C (HCV) infection affects cognitive function in children. The aim of the study was to assess the impact of HCV infectio... NHA Faddan,GA Shehata,HAA Elhafeez,... - 《Journal of Viral Hepatitis》 被引量: 3发表: 2015年 Protective efficacy and hepatiti...
chemokine and growth factor responses. This atlas of transcriptional patterns induced by cytokines enabled the reliable prediction of signaling activities in distinct cell populations in infectious diseases, chronic inflammation and cancer using bulk and single-cell transcriptomic data. CytoSig revealed previo...
Myelin-specific regulatory T cells accumulate in the CNS but fail to control autoimmune inflammation . Nat Med 2007 ; 13 : 423 – 431 . Article CAS PubMed PubMed Central Google Scholar Ehrenstein MR, Evans JG, Singh A, Moore S, Warnes G, Isenberg DA et al . Compromised function of ...
To clarify the physiological relevance of this latter function, we examined the effect of NLRP3 on NF-κB activation and cytokine induction in RNA-interference-based NLRP3-knockdown cell lines generated from the human monocytic cell line THP-1. Knocking down NLRP3 reduced NF-κB activation and ...
Cytokine messenger RNA expression for IL-3, IL-4, IL-5, and granulocyte/macrophage-colony-stimulating factor in the nasal mucosa after local allergen provo... Tissue eosinophilia is characteristic of human atopic allergic inflammation, although the mechanism is largely unknown. In this study we tes...
Previous studies show that exercise training and caloric restriction improve cardiac function in obesity. However, the molecular mechanisms underlying this... EC Paulino,JCB Ferreira,LR Bechara,... - 《Hypertension》 被引量: 90发表: 2010年 Effects of exercise on insulin sensitivity, inflammatory cy...
et al. Inhibition of interleukin-1 by anakinra improves vascular and left ventricular function in patients with rheumatoid arthritis. Circulation 117, 2662–2669 (2008). Article CAS PubMed Google Scholar Matsuki, T. et al. Involvement of tumor necrosis factor-α in the development of T cell-...