The papain-like cysteine protease family (MEROPS family C1) belongs to the CA clan. These proteins are about 30 kDa in size and fold into two domains that form a cleft containing the active site (Fig. 1K). Members of this protein family are found in viruses, bacteria, and eukaryotes. ...
release inside the endo-lysosomal pathway,1 the extracellular environment,2,3,5,6 or the cytoplasm.4 AEC strategies that depend on extracellular delivery make use of viral epitopes with a free of charge C-terminus. Protease manifestation levels as well as the amino acids/protease cleavage site ...
Four medically relevantD. pteronyssinusallergens are proteolytic enzymes that are believed to participate in the digestion process: the major allergen Der p 1 is a papain-like cysteine protease (CP) of the C1A subfamily; Der p 3, Der p 6 and Der p 9 are serine proteases (SP) of the S1...
In plants, cystatins are natural and specific inhibitors of cysteine proteases of the papain C1A family that generally block C1A proteases by a tight and reversible interaction [1]. Several cystatin functions have been proposed, but all involve a balanced interplay with a cysteine protease to reg...
Cystatin M/E is a member of a superfamily of evolutionarily-related cysteine protease inhibitors that provide regulatory and protective functions against u... PLJM Zeeuwen,T Cheng,J Schalkwijk - 《Journal of Investigative Dermatology》 被引量: 101发表: 2009年 Cystatin B inhibition of TRAIL-induced...
Almost all protease families have been associated with plant development, particularly senescence, which is the final developmental stage of every organ before cell death. Proteolysis remobilizes and recycles nitrogen from senescent organs that is requir
Using multivariate logistic regression, five admission-related factors were evaluated. The area under the curve (AUC) and the shrinkage coefficient were used, respectively, to assess the model's capability to discriminate and its calibration A count of 320 patients completed the enrollment process for...
Proteases play causal roles in the malignant progression of human tumors. This review centers on the roles in this process of cysteine cathepsins, i.e., peptidases belonging to the papain family (C1) of the CA clan of cysteine proteases. Cysteine catheps
pathological processes, from thebulkdigestion of protein, on the one hand, to highly regulated rate-determining and specific peptide-bond cleavages at the opposite extreme. They are implicated in a number of human pathologies, and the development of cysteineprotease inhibitorsas drugs is a very ...
Mason, Mouse cathepsin M, a placenta-specific lysosomal cysteine protease related to cathepsins L and P, Biochim. Biophys. Acta 1491 (2000) 289-294.Sol-Church, K., Frenck, J., and Mason, R. W. (2000). Mouse cathepsin M, a placenta-spe- cific lysosomal cysteine protease related to ...